INT158773

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Context Info
Confidence 0.34
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
microglia 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 1 99.76 Very High Very High Very High
tolerance 9 99.30 Very High Very High Very High
Morphine 9 98.94 Very High Very High Very High
Spinal cord 1 96.64 Very High Very High Very High
Calcitonin gene-related peptide 7 95.92 Very High Very High Very High
analgesia 4 84.28 Quite High
Pain 1 75.72 Quite High
Disease Link Frequency Relevance Heat
Pain 1 75.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 7-d treatment with morphine induced tolerance to the antinociceptive effect and increased phosphorylated ERK localized in astrocytes and phosphorylated p38 enriched in microglia, both effects being inhibited by blocking CGRP receptors.
Positive_regulation (increased) of Localization (localized) of ERK in microglia associated with tolerance, antinociceptive, calcitonin gene-related peptide and morphine
1) Confidence 0.34 Published 2009 Journal FASEB J. Section Abstract Doc Link 19299480 Disease Relevance 0.08 Pain Relevance 1.64

General Comments

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