INT158775

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf, Ephb1) plasma membrane (Tnf, Ephb1) endosome (Ephb1)
extracellular space (Tnf) extracellular region (Tnf) intracellular (Tnf)
Anatomy Link Frequency
spinal cord 2
Tnf (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 9 99.62 Very High Very High Very High
Morphine 9 99.42 Very High Very High Very High
Calcitonin gene-related peptide 7 98.94 Very High Very High Very High
analgesia 4 95.96 Very High Very High Very High
Spinal cord 1 94.72 High High
Pain 1 87.40 High High
Antinociceptive 1 84.00 Quite High
Disease Link Frequency Relevance Heat
Pain 1 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK-dependent up-regulation of IL-1beta, TNF-alpha, and microsomal prostaglandin E synthase-1 (mPGES-1) in astrocytes and p38-dependent up-regulation of IL-6 in microglia in the rat spinal cord.
Regulation (regulating) of TNF-alpha Regulation (regulation) of ERK in spinal cord associated with tolerance, spinal cord, morphine and calcitonin gene-related peptide
1) Confidence 0.18 Published 2009 Journal FASEB J. Section Abstract Doc Link 19299480 Disease Relevance 0.09 Pain Relevance 1.52

General Comments

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