INT1588

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Context Info
Confidence 0.26
First Reported 1979
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.57
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK)
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 10 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
opiate 3 87.16 High High
antagonist 1 83.16 Quite High
agonist 1 82.52 Quite High
Disease Link Frequency Relevance Heat
Aggression 1 90.80 High High
Disease 2 88.08 High High
Death 1 83.04 Quite High
Gallstones 1 79.04 Quite High
Pancreatitis 1 76.08 Quite High
Carcinoma 1 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium ion at physiological concentrations decreases substantially the binding of enkephalins but only slightly decreases endorphin binding, whereas manganese enhances enkephalin binding but has no effect on endorphin binding.
Positive_regulation (enhances) of enkephalin Binding (binding) of associated with enkephalin
1) Confidence 0.26 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 217869 Disease Relevance 0 Pain Relevance 0.87
SO demonstrated immunoreactivity for VIP, PHI (PHM), neuropeptide Y, CGRP, galanin, somatostatin, substance P, and enkephalin, but no immunoreactivity was observed for bombesin.
Positive_regulation (observed) of enkephalin Binding (immunoreactivity) of associated with somatostatin, neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
2) Confidence 0.25 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8313811 Disease Relevance 0.57 Pain Relevance 0.85

General Comments

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