INT158824

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
prefrontal 1
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 3 96.92 Very High Very High Very High
opiate 6 96.44 Very High Very High Very High
methadone 1 63.20 Quite High
addiction 2 49.68 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 17 99.52 Very High Very High Very High
Apoptosis 72 97.76 Very High Very High Very High
Cv General 4 Under Development 1 96.92 Very High Very High Very High
Hypothermia 13 93.84 High High
Coronary Heart Disease 4 62.76 Quite High
Graft Vs Host Disease 2 61.04 Quite High
Heart Rate Under Development 2 60.36 Quite High
Disease 1 52.04 Quite High
Opiate Addiction 2 49.96 Quite Low
Necrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity.
Phosphorylation (Phosphorylation) of Fas in prefrontal associated with opiate and death
1) Confidence 0.48 Published 2009 Journal Neuroscience Section Title Doc Link 19303913 Disease Relevance 0.51 Pain Relevance 0.24
We measured the membrane-bound form of Fas, which is known to be of far greater importance in the apoptotic process than the soluble form of the molecule that was determined in previous studies [6,8].
Phosphorylation (form) of Fas associated with apoptosis
2) Confidence 0.42 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.89 Pain Relevance 0.05

General Comments

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