INT158829

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.12
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
keratinocyte 1
prefrontal 1
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 6 99.42 Very High Very High Very High
antagonist 38 96.88 Very High Very High Very High
Endocannabinoid 1 96.08 Very High Very High Very High
monoamine 1 93.88 High High
corticosteroid 14 69.00 Quite High
methadone 1 67.28 Quite High
Sicca syndrome 1 60.24 Quite High
withdrawal 7 57.00 Quite High
tolerance 5 49.44 Quite Low
addiction 3 40.24 Quite Low
Disease Link Frequency Relevance Heat
Death 28 99.96 Very High Very High Very High
Eosinophilic Esophagitis 106 99.12 Very High Very High Very High
Apoptosis 76 99.08 Very High Very High Very High
Obesity 12 98.84 Very High Very High Very High
Staphylococcus Infection 21 98.56 Very High Very High Very High
Aging 104 92.96 High High
Overweight 2 85.60 High High
Cancer 159 80.24 Quite High
Infection 34 79.28 Quite High
Glioma 1 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rationale for the use of IVIg is based on the inhibition of Fas-mediated keratinocyte apoptosis in TEN by naturally occurring Fas-blocking antibodies within the IVIg.
Negative_regulation (inhibition) of Fas in keratinocyte associated with staphylococcus infection and apoptosis
1) Confidence 0.41 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846744 Disease Relevance 0.71 Pain Relevance 0.09
Recently, FADD was found downregulated in the prefrontal cortex of opiate abusers, which suggested an attenuation of Fas death signals in human addicts.
Negative_regulation (attenuation) of Fas in prefrontal associated with opiate and death
2) Confidence 0.25 Published 2009 Journal Neuroscience Section Abstract Doc Link 19303913 Disease Relevance 0.55 Pain Relevance 0.24
Orlistat is a potent inhibitor of Fatty acid synthase (FAS) activity, a key metabolic enzyme responsible for the terminal catalytic step in novo fatty acid biosynthesis [283].
Negative_regulation (inhibitor) of FAS
3) Confidence 0.25 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.01 Pain Relevance 0.14
Likewise, there was a 3-fold decrease in Fas expression levels in EoE subjects compared to the treated EoE subjects (p < 0.05) (Figure 1f).


Negative_regulation (decrease) of Fas associated with eosinophilic esophagitis
4) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.91 Pain Relevance 0
CD95 levels then decrease again at greater ages and in the very oldest donors, values are the same as those observed in young adults.
Negative_regulation (decrease) of CD95
5) Confidence 0.12 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.94 Pain Relevance 0

General Comments

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