INT158848

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
neurons 2
oocytes 2
Accn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 98.44 Very High Very High Very High
aPETx2 6 97.72 Very High Very High Very High
Pain 9 94.68 High High
Peripheral nervous system 2 92.68 High High
ASIC 4 88.96 High High
c fibre 4 73.60 Quite High
Spinal cord 7 18.68 Low Low
nociceptor 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 98.44 Very High Very High Very High
Pain 4 94.68 High High
Nociception 2 70.76 Quite High
Targeted Disruption 4 30.16 Quite Low
Cough 5 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These relative proportions might be a slight overestimation of the situation under physiological conditions, since tracer application caused, to some extent, local inflammation, and inflammatory conditions lead to increased ASIC3 transcription in vivo and to an increased number of ASIC3 expressing neurons in vitro [46,47].
Negative_regulation (number) of Gene_expression (expressing) of ASIC3 in neurons associated with inflammation
1) Confidence 0.37 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.42 Pain Relevance 0.43
APETx2, a 42-residue peptide toxin isolated from the sea anemone Anthopleura elegantissima, is the only known selective inhibitor of ASIC3 channels.
Negative_regulation (inhibitor) of Gene_expression (channels) of ASIC3 associated with apetx2
2) Confidence 0.33 Published 2009 Journal Toxicon Section Abstract Doc Link 19306891 Disease Relevance 0.09 Pain Relevance 0.45
The folded synthetic toxin had an IC(50) of 57 nM for inhibition of rat ASIC3 channels expressed in Xenopus oocytes, in agreement with the IC(50) reported for the native toxin (63 nM).
Negative_regulation (inhibition) of Gene_expression (expressed) of ASIC3 in oocytes
3) Confidence 0.33 Published 2009 Journal Toxicon Section Abstract Doc Link 19306891 Disease Relevance 0.09 Pain Relevance 0.43

General Comments

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