INT158863

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 4
Speculated 6
Reported most in Body
Documents 84
Total Number 89
Disease Relevance 40.30
Pain Relevance 10.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
liver 16
muscle 3
B cells 3
hearts 3
retina 2
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 266 100.00 Very High Very High Very High
Inflammatory mediators 13 100.00 Very High Very High Very High
tolerance 468 99.92 Very High Very High Very High
intrathecal 1 99.56 Very High Very High Very High
Bioavailability 10 99.24 Very High Very High Very High
ischemia 52 99.20 Very High Very High Very High
Paracetamol 80 98.94 Very High Very High Very High
cINOD 39 98.90 Very High Very High Very High
Thermal hyperalgesia 2 97.44 Very High Very High Very High
allodynia 2 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 758 100.00 Very High Very High Very High
INFLAMMATION 322 100.00 Very High Very High Very High
Deafness 18 100.00 Very High Very High Very High
Impaired Glucose Tolerance 288 99.92 Very High Very High Very High
Hyperglycemia 235 99.92 Very High Very High Very High
Hyperinsulinism 25 99.88 Very High Very High Very High
Insulin Resistance 611 99.84 Very High Very High Very High
Diabetes Mellitus 1289 99.60 Very High Very High Very High
Neurodegenerative Disease 84 99.42 Very High Very High Very High
Cv Unclassified Under Development 659 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present report we compare the LEC loss, abnormal expansion of the bow region, abnormal cortical ROS, and the formation of DNA oxidative adducts (8-Oxo-2'-deoxyguanosine abbreviated here as 8-OH-dG) in the lens cortex caused by head-only X-irradiation, to the same alterations seen in ARC.
Negative_regulation (loss) of ROS in lens associated with aids-related complex
1) Confidence 0.35 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.54 Pain Relevance 0
Since ROS are not reduced by the normal anti-oxidizing system in a body, they can cause tissue reperfusion injury [1].
Neg (not) Negative_regulation (reduced) of ROS in body associated with reperfusion injury
2) Confidence 0.20 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.29 Pain Relevance 0.19
Since the measurement was done after the ROS was removed in this manner, blocking of the Ach vascular relaxation induction effect is assumed to be the result of the direct vascular endothelium injury by ROS, not the result of NO inactivation by ROS [20].
Negative_regulation (removed) of ROS in vascular endothelium associated with injury
3) Confidence 0.20 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.46 Pain Relevance 0.26
Our results showed that ERK activation was suppressed and the synaptophysin level was preserved when the ROS level was decreased by lutein (Figs 1 and 3), indicating that ROS activated ERK to reduce synaptophysin levels in diabetes, as AT1R signalling did in our previous study [8].
Negative_regulation (decreased) of ROS associated with diabetes mellitus
4) Confidence 0.19 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.35 Pain Relevance 0.11
Reduction of ROS in liver is a potentially effective strategy to improve insulin resistance.
Negative_regulation (Reduction) of ROS in liver associated with insulin resistance
5) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.15 Pain Relevance 0
With regard to the changes in expression and tyrosine phosphorylation of IRS-1, reduction of ROS attenuated phosphorylation of IRS-1 at the Ser307 residue.
Negative_regulation (reduction) of ROS
6) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.15 Pain Relevance 0
However, the phosphorylation level of Akt, a key signal molecule mediating the metabolic actions of insulin, was not altered by reduction of ROS.
Negative_regulation (reduction) of ROS
7) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.22 Pain Relevance 0.08
To elucidate the effect of the reduction of hepatic ROS on glucose metabolism, we investigated the effect of SOD1 overexpression in liver on blood glucose level in db/db mice.
Negative_regulation (reduction) of ROS in liver
8) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.23 Pain Relevance 0
These results suggest that the reduction of ROS derived from mitochondria may play a key role in the improvement of insulin sensitivity.
Negative_regulation (reduction) of ROS
9) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.33 Pain Relevance 0.05
Thus, whereas we cannot exclude the possibility that the reduction of ROS in liver altered peripheral insulin sensitivity, it is likely that the improvement in glucose level following reduction of ROS in the liver is mainly caused by reduced expression of gluconeogenic genes.
Negative_regulation (reduction) of ROS in liver
10) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.63 Pain Relevance 0
Therefore, amelioration of glucose tolerance by reduction of ROS in the liver in db/db mice might possibly be due to an increase in insulin signaling.
Negative_regulation (reduction) of ROS in liver associated with tolerance and impaired glucose tolerance
11) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.31 Pain Relevance 0.09
Probably because of the opposite changes of insulin signal at IRS-1 and IRS-2, Akt phosphorylation was not affected by reduction of ROS.
Negative_regulation (reduction) of ROS
12) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.12 Pain Relevance 0
expression is at least in part involved in the amelioration of liver insulin resistance by the reduction of ROS.
Negative_regulation (reduction) of ROS in liver associated with insulin resistance
13) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.34 Pain Relevance 0.04
CONCLUSIONS—Our results indicate that the reduction of ROS is a potential therapeutic target of liver insulin resistance, at least partly by the reduced expression of PGC-1?.



Negative_regulation (reduction) of ROS in liver associated with insulin resistance
14) Confidence 0.17 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494675 Disease Relevance 0.42 Pain Relevance 0
Thus, it is likely that reduction of ROS increases the phosphorylation and expression of IRS-1 through a reduction of JNK activity.
Negative_regulation (reduction) of ROS
15) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.13 Pain Relevance 0
In the present study, reduction of ROS also attenuated JNK activation.
Negative_regulation (reduction) of ROS
16) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.14 Pain Relevance 0
Interestingly, reduction of ROS increased tyrosine phosphorylation of IRS-1 but decreased tyrosine phosphorylation of IRS-2.
Negative_regulation (reduction) of ROS
17) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.17 Pain Relevance 0
Thus, reduction of ROS in liver might reduce the gene expression of IRS-2 by attenuating CREB phosphorylation.
Negative_regulation (reduction) of ROS in liver
18) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.07 Pain Relevance 0
associated with reduction of ROS in liver is accompanied by reduced phosphorylation of CREB.


Negative_regulation (reduction) of ROS in liver
19) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.08 Pain Relevance 0
The profound control of AuNPs over the anti oxidant enzymes such as GSH, SOD, Catalase and GPx in diabetic mice to normal, by inhibition of lipid peroxidation and ROS generation during hyperglycemia evidence their anti-oxidant effect during hyperglycemia.
Negative_regulation (inhibition) of ROS associated with hyperglycemia and diabetes mellitus
20) Confidence 0.16 Published 2010 Journal J Nanobiotechnology Section Abstract Doc Link PMC2914719 Disease Relevance 1.03 Pain Relevance 0

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