INT158877

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 5.14
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
PVN 3
spinal 2
MeA 1
PRS (Homo sapiens)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 99.40 Very High Very High Very High
amygdala 9 98.56 Very High Very High Very High
Antinociceptive 3 88.00 High High
nud 3 76.76 Quite High
Hyperalgesia 3 70.64 Quite High
spastic colon 9 63.52 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

30 100.00 Very High Very High Very High
Stress 30 100.00 Very High Very High Very High
Dyspepsia 3 76.76 Quite High
Hyperalgesia 3 70.64 Quite High
Hypersensitivity 3 60.88 Quite High
Functional Bowel Disorder 3 57.08 Quite High
Sprains And Strains 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study shows that PRS enhances Fos protein expression induced by CRD at the spinal and supraspinal levels in rats.
PRS Positive_regulation (enhances) of Gene_expression (expression) of Fos in spinal associated with stress
1) Confidence 0.09 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309441 Disease Relevance 0.88 Pain Relevance 0.41
The combination of both stimuli, PRS and CRD, markedly increased this Fos overexpression in the sacral spinal cord section, PVN and MeA, but not in NTS.
PRS Neg (not) Positive_regulation (increased) of Gene_expression (overexpression) of Fos in PVN associated with stress, amygdala and spinal cord
2) Confidence 0.05 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309441 Disease Relevance 1.02 Pain Relevance 0.56
The combination of both stimuli, PRS and CRD, markedly increased this Fos overexpression in the sacral spinal cord section, PVN and MeA, but not in NTS.
PRS Neg (not) Positive_regulation (increased) of in MeA Gene_expression (overexpression) of Fos in PVN associated with stress, amygdala and spinal cord
3) Confidence 0.02 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309441 Disease Relevance 1.02 Pain Relevance 0.56

General Comments

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