INT15888

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Context Info
Confidence 0.69
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 42
Total Number 42
Disease Relevance 35.76
Pain Relevance 10.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nbr1) lysosome (Nbr1) cytoplasm (Nbr1)
Anatomy Link Frequency
plasma 2
epithelial cells 2
peritoneal fluid 2
lymph node 1
myometrium 1
Nbr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Taxol 3 99.76 Very High Very High Very High
Migraine 40 99.68 Very High Very High Very High
anesthesia 2 99.46 Very High Very High Very High
endometriosis 92 99.40 Very High Very High Very High
Dismenorea 104 99.28 Very High Very High Very High
headache 2 98.72 Very High Very High Very High
Pain 15 97.56 Very High Very High Very High
dexamethasone 1 95.60 Very High Very High Very High
imagery 22 95.20 Very High Very High Very High
pain pelvic 8 94.20 High High
Disease Link Frequency Relevance Heat
Cancer 199 100.00 Very High Very High Very High
Metastasis 40 99.90 Very High Very High Very High
Cyst 24 99.88 Very High Very High Very High
Gastrointestinal Disease 1 99.80 Very High Very High Very High
Pressure And Volume Under Development 20 99.76 Very High Very High Very High
Headache 40 99.68 Very High Very High Very High
Abscess 6 99.66 Very High Very High Very High
Multiple Myeloma 3 99.58 Very High Very High Very High
Reprotox - General 3 13 99.50 Very High Very High Very High
Endometriosis (extended) 56 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the elevation of serum CA125 levels in patients with adenomyosis may be due to greatly increased production of CA125 by heterotopic epithelial cells, in addition to the production of CA125 by eutopic ones.
Positive_regulation (elevation) of CA125 in epithelial cells associated with dismenorea
1) Confidence 0.69 Published 1990 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 2212818 Disease Relevance 0.16 Pain Relevance 0.16
Human eutopic and heterotopic endometrium were cultured and epithelial cells were isolated from stromal cells by the modified method of Satyaswaroop et al. in order to investigate the cause of elevated serum CA125 levels in patients with adenomyosis.
Positive_regulation (elevated) of CA125 in epithelial cells associated with dismenorea
2) Confidence 0.69 Published 1990 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 2212818 Disease Relevance 0.10 Pain Relevance 0.10
Cyst fluid also revealed a highly elevated CA-125 level.
Positive_regulation (elevated) of CA-125 associated with cyst
3) Confidence 0.67 Published 2008 Journal Intern. Med. Section Abstract Doc Link 18480581 Disease Relevance 0.73 Pain Relevance 0.12
Chest roentgenograms disclosed a small amount of bilateral pleural effusion, the examination of which exposed a sterile serous exudate with a markedly increased CA-125 level.
Positive_regulation (increased) of CA-125 in Chest associated with pleural effusion
4) Confidence 0.67 Published 2008 Journal Intern. Med. Section Abstract Doc Link 18480581 Disease Relevance 0.76 Pain Relevance 0.13
Spontaneous rupture of idiopathic thymic abscess with a markedly increased CA-125 level.
Positive_regulation (increased) of CA-125 associated with spontaneous rupture and abscess
5) Confidence 0.67 Published 2008 Journal Intern. Med. Section Title Doc Link 18480581 Disease Relevance 0.80 Pain Relevance 0.13
In normal women, plasma concentrations of CA125 are increased slightly at ovulation and significantly during menstruation.
Positive_regulation (increased) of CA125 in plasma
6) Confidence 0.65 Published 1995 Journal Hum. Reprod. Update Section Abstract Doc Link 15726771 Disease Relevance 0.50 Pain Relevance 0.21
Plasma concentrations of CA125 are markedly elevated in women with cystic ovarian endometriosis and/or deeply infiltrating endometriosis, but not, or only slightly, in the luteal phase of women with minimal or mild endometriosis.
Positive_regulation (elevated) of CA125 in Plasma associated with endometriosis
7) Confidence 0.65 Published 1995 Journal Hum. Reprod. Update Section Abstract Doc Link 15726771 Disease Relevance 1.05 Pain Relevance 0.44
This study demonstrated one of the causes of increased serum CA125 in patients with adenomyosis.
Positive_regulation (increased) of CA125 associated with dismenorea
8) Confidence 0.58 Published 1989 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 2723482 Disease Relevance 0.10 Pain Relevance 0.10
Also, laboratory studies showed elevated CA125 and alpha fetoprotein levels suggesting an initial diagnosis of ESS.
Positive_regulation (elevated) of CA125 associated with endodermal sinus tumor
9) Confidence 0.47 Published 2006 Journal Int. J. Gynecol. Cancer Section Abstract Doc Link 16515609 Disease Relevance 1.37 Pain Relevance 0.14
From these findings, it was suggested that one of the causes of serum CA125 increase in patients with adenomyosis appeared to be the increase in the ectopic endometrial tissues in the myometrium and direct shedding from ectopic endometrial cells into peripheral circulation.
Positive_regulation (increase) of CA125 in myometrium associated with dismenorea
10) Confidence 0.47 Published 1988 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 3163715 Disease Relevance 1.09 Pain Relevance 0.31
Seven of these patients had positive results in transvaginal ultrasonography; 61%(11/18) patients had elevated CA125 levels.
Positive_regulation (elevated) of CA125
11) Confidence 0.46 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 19830869 Disease Relevance 0.08 Pain Relevance 0
All had elevated preoperative CA125 levels with a median value of 171 micro/ml (range 46-383).
Positive_regulation (elevated) of CA125
12) Confidence 0.46 Published 2002 Journal Int. J. Gynecol. Cancer Section Abstract Doc Link 12445258 Disease Relevance 0.96 Pain Relevance 0.06
Pelvic examination, ultrasonography and magnetic resonance imaging revealed a 7-cm, multicystic ovarian mass with solid component, and her serum CA125 and CA19-9 were elevated to 110.5 and 92 U/mL, respectively.
Positive_regulation (elevated) of CA125
13) Confidence 0.46 Published 2009 Journal J Reprod Med Section Body Doc Link 20120906 Disease Relevance 0 Pain Relevance 0
The increased CA125 level is related to the degree of proteinuria and after prednisolone and cyclosporine therapy, proteinuria and the CA125 level gradually decreased.
Positive_regulation (increased) of CA125 associated with proteinuria
14) Confidence 0.46 Published 2002 Journal Am. J. Nephrol. Section Abstract Doc Link 12169874 Disease Relevance 1.33 Pain Relevance 0.08
These data are consistent with the concept that CA125 in normal women is mainly derived from the endometrium and the irritated peritoneum.
Positive_regulation (derived) of CA125 in peritoneum
15) Confidence 0.43 Published 1995 Journal Hum. Reprod. Update Section Abstract Doc Link 15726771 Disease Relevance 0.82 Pain Relevance 0.33
Migraine patients have interictally a deficient habituation of the nBR which is inversely related to attack frequency, suggesting that it is not due to trigeminal sensitization.
Positive_regulation (habituation) of nBR associated with migraine
16) Confidence 0.42 Published 2007 Journal Brain Section Abstract Doc Link 17251239 Disease Relevance 1.27 Pain Relevance 1.35
Elevated levels of serum CA125 were noted in 52 of 66 patients with endometriosis in which the positive rate was 78.8% and mean was 119.8 U/ml.
Positive_regulation (levels) of CA125 associated with endometriosis
17) Confidence 0.42 Published 1987 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 3475378 Disease Relevance 0.62 Pain Relevance 0.42
In patients with endometriosis, although CA125 concentrations in peritoneal fluid decreased transiently during conservative hormonal treatment, an increase in CA125 concentrations in peritoneal fluid was observed again after treatment. 5.
Positive_regulation (increase) of CA125 in peritoneal fluid associated with endometriosis
18) Confidence 0.40 Published 1989 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 2746065 Disease Relevance 0.82 Pain Relevance 0.22
We elicited the nBR by stimulating the right supraorbital region with a custom-built electrode in 16 MO between attacks, 15 HV and 14 HV-F.
Positive_regulation (elicited) of nBR associated with migraine
19) Confidence 0.39 Published 2007 Journal Brain Section Abstract Doc Link 17251239 Disease Relevance 1.41 Pain Relevance 1.26
Since serum CA-125 concentrations are increased in women with endometriosis, the authors evaluated CA-125 levels to determine whether this serum test would be useful in differentiating between pelvic pain due to endometriosis and other causes.
Positive_regulation (increased) of CA-125 associated with endometriosis and pain pelvic
20) Confidence 0.39 Published 1989 Journal Fertil. Steril. Section Abstract Doc Link 2910718 Disease Relevance 0.64 Pain Relevance 0.44

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