INT158889

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.25
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) DNA binding (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
brain 1
nucleus 1
Smad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 33 98.16 Very High Very High Very High
cytokine 38 91.68 High High
Central nervous system 6 89.84 High High
Hippocampus 39 80.64 Quite High
IPN 2 75.00 Quite High
antagonist 13 48.24 Quite Low
antidepressant 24 46.52 Quite Low
Inflammation 28 35.04 Quite Low
fibrosis 68 33.68 Quite Low
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 86 95.12 Very High Very High Very High
Injury 11 91.00 High High
Urological Neuroanatomy 3 82.48 Quite High
Inflammatory Pain 2 75.00 Quite High
Apoptosis 29 73.32 Quite High
Death 6 66.24 Quite High
INFLAMMATION 29 35.04 Quite Low
Fibrosis 90 33.68 Quite Low
Neurodegenerative Disease 10 27.88 Quite Low
Infection 60 25.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon complex formation the Smad 2/3-4 complex translocates to the nucleus and regulates the response to TGF-?
Gene_expression (/) of Smad 2 in nucleus
1) Confidence 0.65 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.16 Pain Relevance 0.09
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Gene_expression (expression) of Smad2 in brain
2) Confidence 0.54 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.13 Pain Relevance 0.13
1 mRNA expression in PSCs through an ERK-dependent but Smad2/3-independent pathway.
Gene_expression (expression) of Smad2
3) Confidence 0.22 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.40 Pain Relevance 0
Together, these data suggest distinct roles of Smad2-, Smad3- and ERK-dependent pathways in TGF-?
Gene_expression (roles) of Smad2
4) Confidence 0.22 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.40 Pain Relevance 0
of Smad2, one of the major mediators of TGF-?
Gene_expression (one) of Smad2
5) Confidence 0.15 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.16 Pain Relevance 0.29

General Comments

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