INT158896

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1)
cytoplasm (Tjp1)
Anatomy Link Frequency
brain 2
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 2 75.00 Quite High
Inflammation 8 25.00 Low Low
Pain 2 25.00 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 20 80.48 Quite High
Inflammatory Pain 2 75.00 Quite High
Heart Rate Under Development 2 72.72 Quite High
Adult Respiratory Distress Syndrome 14 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 3 5.00 Very Low Very Low Very Low
Brain Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis with brain tissue homogenates show that the protein levels of the tight junction proteins ZO-1 and occludin in the ultrasound treated region is not changed compared to non-treated regions (Figure 3A).
Neg (not) Positive_regulation (changed) of ZO-1 in brain
1) Confidence 0.31 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
After a 5 day culture period, cells were either lysed for western analysis of tight junction protein expressin (claudin 3, 4, 5, 7, 8, and 18, occludin, ZO-1, and JAM-A) and MAPk (JNK, ERK, an p38) signaling activation, or barrier function was examined by measuring transepithelial resistance (TER) or the flux of two molecular tracers (5 and 20 Å).
Positive_regulation (activation) of ZO-1
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2892473 Disease Relevance 0.22 Pain Relevance 0
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Positive_regulation (increased) of ZO-1 in brain
3) Confidence 0.10 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox