INT158898

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.06
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
brain 4
ileum 2
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 35 96.92 Very High Very High Very High
Inflammation 18 87.00 High High
Cholecystokinin 2 76.72 Quite High
IPN 2 75.00 Quite High
cytokine 10 61.64 Quite High
Bile 64 54.44 Quite High
Pain 2 25.00 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 17 99.60 Very High Very High Very High
Obesity 32 97.82 Very High Very High Very High
Reperfusion Injury 21 97.68 Very High Very High Very High
Cv Unclassified Under Development 28 96.92 Very High Very High Very High
Hyperphagia 1 88.88 High High
INFLAMMATION 18 87.00 High High
Metabolic Disorder 9 84.96 Quite High
Inflammatory Pain 2 75.00 Quite High
Targeted Disruption 2 74.56 Quite High
Injury 6 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Positive_regulation (increased) of Gene_expression (expression) of occludin in brain
1) Confidence 0.22 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14
Western blot analysis with brain tissue homogenates show that the protein levels of the tight junction proteins ZO-1 and occludin in the ultrasound treated region is not changed compared to non-treated regions (Figure 3A).
Neg (not) Positive_regulation (changed) of Gene_expression (levels) of occludin in brain
2) Confidence 0.22 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
As described above, the OLETF rats fed the standard diet did not exhibit any increase in intestinal permeability in comparison to the counter strain LETO rats fed the same diet, although 2 obese mouse models, the leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) strains, reportedly showed increases in intestinal permeability with a concomitant reduction in the expression of TJ proteins, ZO-1 and occludin [5].
Positive_regulation (increases) of Gene_expression (expression) of occludin associated with obesity and sprains and strains
3) Confidence 0.19 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 1.24 Pain Relevance 0.28
Treatment with U0126 significantly increased occludin expression in sham monolayers only.
Positive_regulation (increased) of Gene_expression (expression) of occludin
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry using control sections of rat ileum demonstrated the expression of claudin-1, claudin-2, claudin-3, claudin-4, claudin-5, ZO-1, and occludin.
Positive_regulation (demonstrated) of Gene_expression (expression) of occludin in ileum
5) Confidence 0.17 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.68 Pain Relevance 0.16

General Comments

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