INT158903

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Smad3) intracellular (Smad3) protein binding transcription factor activity (Smad3)
DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3)
Anatomy Link Frequency
brain 1
Smad3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 2 75.00 Quite High
antagonist 6 48.88 Quite Low
cytokine 15 43.44 Quite Low
Inflammation 7 35.68 Quite Low
fibrosis 34 34.32 Quite Low
Pain 2 25.00 Low Low
Chronic pancreatitis 8 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 43 95.76 Very High Very High Very High
Inflammatory Pain 2 75.00 Quite High
INFLAMMATION 4 35.68 Quite Low
Fibrosis 45 34.32 Quite Low
Pancreatitis 11 5.00 Very Low Very Low Very Low
Pancreatic Cancer 8 5.00 Very Low Very Low Very Low
Cirrhosis 7 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Gene_expression (expression) of Smad3 in brain
1) Confidence 0.56 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.13 Pain Relevance 0.13
Together, these data suggest distinct roles of Smad2-, Smad3- and ERK-dependent pathways in TGF-?
Gene_expression (roles) of Smad3
2) Confidence 0.26 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.40 Pain Relevance 0

General Comments

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