INT158946

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Pparg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3 100.00 Very High Very High Very High
antagonist 5 99.56 Very High Very High Very High
qutenza 3 92.48 High High
agonist 6 80.48 Quite High
cytokine 1 76.20 Quite High
cINOD 2 52.88 Quite High
COX2 1 25.00 Low Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High
Stress 8 93.80 High High
Middle Cerebral Artery Infarction 3 93.12 High High
Stroke 4 81.96 Quite High
Shock 1 79.68 Quite High
Sprains And Strains 1 75.00 Quite High
Injury 1 50.56 Quite High
Colitis 1 48.16 Quite Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Polycystic Ovary Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, pharmacological inhibition and/or genetic deletion of 5-LO inhibited rosiglitazone-induced neuroprotection and downregulation of inflammatory gene expression, LXA(4) synthesis and PPARgamma transcriptional activity in rodents.
Negative_regulation (downregulation) of PPARgamma associated with inflammation
1) Confidence 0.43 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321784 Disease Relevance 0.72 Pain Relevance 0.26
In a subsequent experiment, neonatal rats were treated with acyline (GnRH antagonist) which significantly reduced FSH (p < 0.05) but not levels of mRNA for PPARgamma.
Negative_regulation (reduced) of PPARgamma associated with antagonist
2) Confidence 0.40 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.05
In rats pretreated with EcN, a significant downregulation of mRNA and protein expression for IL-1beta, COX-2 and PPARgamma and increased expression of HSP70 without major change in activation of NFkappaB were observed.
Negative_regulation (downregulation) of PPARgamma
3) Confidence 0.09 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.82 Pain Relevance 0.20

General Comments

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