INT158954

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 0
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga1) cytoplasm (Cnga1)
Anatomy Link Frequency
neuronal 1
endothelial cells 1
ganglia 1
heart 1
secretory cells 1
Cnga1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 3 99.90 Very High Very High Very High
Gabapentin 3 99.08 Very High Very High Very High
hCN2 25 94.60 High High
Analgesic 3 93.12 High High
anticonvulsant 2 92.52 High High
substantia gelatinosa 14 92.28 High High
Pyramidal cell 30 92.12 High High
Central nervous system 15 89.12 High High
HCN1 46 88.80 High High
Action potential 21 88.80 High High
Disease Link Frequency Relevance Heat
Dislocations 7 22.08 Low Low
Decapitation 7 20.80 Low Low
Aging 29 7.60 Low Low
Depression 14 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Parkinson's Disease 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low
Dyskinesias 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we tested the effect of intrathecal ZD7288, an HCN channel inhibitor, and its interaction with intrathecal gabapentin in the rat formalin test.
Regulation (effect) of HCN channel associated with gabapentin and intrathecal
1) Confidence 0.39 Published 2009 Journal Eur J Anaesthesiol Section Abstract Doc Link 19322095 Disease Relevance 0 Pain Relevance 0.54
Nevertheless, studies on isolated heart pacemaker cells have shown that NO (through cGMP) can directly affect HCN channels (Herring et al., 2001).
Regulation (affect) of HCN in heart
2) Confidence 0.34 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0
To study the modulation of HCN channel function by NO, a series of long hyperpolarizing voltage steps (Vstep) to activate Ih were applied followed by a shorter step to a fixed potential (Vfixed; Fig. 1).
Regulation (modulation) of HCN
3) Confidence 0.34 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.07
For example, exogenous NO modified oscillatory activity in thalamocortical relay neurones by acting on HCN channels (Pape & Mager, 1992); in trigeminal motor and mesencephalic neurones, NO and cGMP reversibly depolarized the membrane and reduced the firing threshold by a presumed action on HCN channels (Abudara et al., 2002; Pose et al., 2003); the cGMP derivative 8-bromo-cGMP concentration-dependently shifted the HCN channel activation curve in sensory ganglia in the depolarized direction (Ingram & Williams, 1996); and, in the substantia gelatinosa, 8-bromo-cGMP or exogenous NO enhanced Ih (Kim et al., 2005).
Regulation (acting) of HCN in ganglia associated with substantia gelatinosa
4) Confidence 0.25 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.15
m (n = 5 of 5) DEA/NO had no effect on HCN channels.
Neg (no) Regulation (effect) of HCN
5) Confidence 0.25 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0
In this respect, it may be relevant that most previous publications dealing with NO/cGMP regulation of HCN channels in central neurones have used less disruptive sharp electrodes (Pape & Mager, 1992; Abudara et al., 2002; Pose et al., 2003).
Neg (NO) Regulation (regulation) of HCN
6) Confidence 0.25 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.04
HCN channels have been identified in secretory cells including GnRH neurons, pancreatic ?
Regulation (channels) of HCN in secretory cells
7) Confidence 0.23 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.12
Although HCN channels are commonly regarded as being regulated by the more potent cyclic nucleotide, cAMP, the responsiveness of DCN neuronal channels to NO may reflect the presence of guanylyl cyclase in the vicinity of the channels, producing cGMP in the low micromolar range needed to be effective (DiFrancesco & Tortora,1991; Ludwig et al., 1998; Zagotta et al., 2003; Zhou et al., 2004).
Regulation (regulated) of HCN in neuronal
8) Confidence 0.15 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.16
Most recently, studies on rat optic nerve found that NO coming from endothelial cells persistently depolarizes axons through cGMP acting on HCN channels (Garthwaite et al., 2006).
Regulation (acting) of HCN in endothelial cells
9) Confidence 0.15 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.12
The molecular target of SKF83959 on HCN channel, however, remains to be identified.
Regulation (target) of HCN
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948503 Disease Relevance 0 Pain Relevance 0.19

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