INT158964

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FosB, Creb1) DNA binding (FosB, Creb1) nucleoplasm (Creb1)
mitochondrion (Creb1) nucleolus (Creb1) transcription factor binding (Creb1)
FosB (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 16 100.00 Very High Very High Very High
Dopamine 2 93.48 High High
Nicotine 4 89.20 High High
alcohol 10 75.00 Quite High
Nucleus accumbens 2 73.32 Quite High
addiction 2 62.76 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that enhanced sensitivity of AA rats to morphine is related to augmented morphine-induced expression of FosB/DeltaFosB and morphine-induced reduction of pCREB levels.
FosB Negative_regulation (reduction) of pCREB associated with morphine
1) Confidence 0.21 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 1.03
These findings suggest that enhanced sensitivity of AA rats to morphine is related to augmented morphine-induced expression of FosB/DeltaFosB and morphine-induced reduction of pCREB levels.
DeltaFosB Negative_regulation (reduction) of pCREB associated with morphine
2) Confidence 0.13 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 1.03

General Comments

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