INT158977

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.44
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SLC2A1) plasma membrane (SLC2A1) intracellular (SLC2A1)
carbohydrate metabolic process (SLC2A1) transmembrane transport (SLC2A1) cytoplasm (SLC2A1)
Anatomy Link Frequency
plasma 1
fat cells 1
syncytiotrophoblast 1
SLC2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 56.24 Quite High
cytokine 7 55.20 Quite High
chemokine 2 41.36 Quite Low
Chronic pancreatitis 3 14.16 Low Low
tolerance 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 251 98.20 Very High Very High Very High
Hypoxia 63 98.16 Very High Very High Very High
Pancreatic Cancer 81 97.24 Very High Very High Very High
Targeted Disruption 18 96.48 Very High Very High Very High
Hyperinsulinism 2 88.64 High High
Osteoporosis 6 87.04 High High
Birth Weight 16 64.96 Quite High
INFLAMMATION 5 56.24 Quite High
Hypoglycemia 9 50.00 Quite Low
Cancer 78 48.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects on cellular oxygen consumption were measured amperometrically using a Clark electrode. mRNA expression of GLUT-1 and OPG was determined by RT-PCR; OPG protein secretion by ELISA and HIF-1alpha protein expression by immunoblotting.
Transcription (expression) of GLUT-1
1) Confidence 0.53 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 19327236 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: Pronounced effects of celecoxib on cell viability (reduction), oxygen consumption (stimulation), GLUT-1 mRNA expression (stimulation) and OPG protein secretion (inhibition) in osteoblastic cells were observed only at 50microM-a concentration not reached by therapeutic doses giving plasma concentrations less than 10microM.
Transcription (expression) of GLUT-1 in plasma
2) Confidence 0.53 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 19327236 Disease Relevance 0 Pain Relevance 0
Previously, in a smaller sample with a reduced altitude difference (1600 vs 3100 m), we showed that expression of the GLUT1 glucose transporter on the basal membrane of the syncytiotrophoblast was reduced by ?
Transcription (transporter) of GLUT1 in syncytiotrophoblast
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797307 Disease Relevance 0.06 Pain Relevance 0
After 24h, GLUT-1 mRNA expression was significantly increased.
Transcription (expression) of GLUT-1
4) Confidence 0.46 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 19327236 Disease Relevance 0.06 Pain Relevance 0
A trend toward increased mRNA levels for GLUT1 and CIDEA was observed (P = 0.0594 and P = 0.052, respectively).
Transcription (levels) of GLUT1
5) Confidence 0.37 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.65 Pain Relevance 0
Furthermore, we observed that primarily mRNA levels of the glucose transporter GLUT4 but not GLUT1 were increased by RIP140 silencing in human fat cells, which is in line with data from knock out mice [5].
Transcription (levels) of GLUT1 in fat cells associated with targeted disruption and obesity
6) Confidence 0.37 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.98 Pain Relevance 0
expression improved pancreatic cancer cell proliferation and survival under hypoxic and glucose-deprived conditions in vitro, results that were associated with increased mRNA expression of Glut1 and aldolase A, both glycolytic enzymes [45].
Transcription (expression) of Glut1 associated with hypoxia and pancreatic cancer
7) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.59 Pain Relevance 0.06

General Comments

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