INT158979

Context Info Confidence 0.57 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 3.08 Pain Relevance 0.10

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency stromal cells 3 osteoblasts 1 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 12 98.96 antagonist 8 5.00 metalloproteinase 4 5.00 chemokine 4 5.00 Pain 3 5.00 COX-2 inhibitor 1 5.00 Inflammation 1 5.00 spinal inflammation 1 5.00 rheumatoid arthritis 1 5.00 Osteoarthritis 1 5.00

Disease Link Frequency Relevance Heat Osteolysis 32 98.12 Cancer 132 96.98 Metastasis 184 90.32 Osteoporosis 92 89.20 Lung Cancer 8 61.76 Prostate Cancer 34 21.72 Hypercalcemia 6 11.72 Breast Cancer 24 10.84 Apoptosis 10 5.00 Multiple Myeloma 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also showed that celecoxib at 50microM significantly inhibits OPG protein secretion leading to a compensative increase of mRNA expression.

Negative_regulation (inhibits) of Localization (secretion) of OPG

1) Confidence 0.57 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 19327236 Disease Relevance 0.05 Pain Relevance 0

Osteolysis is characterized by an increase in the ratio of RANKL to OPG; tumor-secreted factors that have been implicated in osteolysis increase this ratio by up-regulating the RANKL expression on osteoblasts/stromal cells or by downregulating OPG secretion [26,34,41].

Negative_regulation (downregulating) of Localization (secretion) of OPG in stromal cells associated with cancer and osteolysis

2) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.51 Pain Relevance 0.05

Osteolysis is characterized by an increase in the ratio of RANKL to OPG; tumor-secreted factors that have been implicated in osteolysis increase this ratio by up-regulating the RANKL expression on osteoblasts/stromal cells or by downregulating OPG secretion [26,34,41].

Negative_regulation (downregulating) of in osteoblasts Localization (secretion) of OPG in stromal cells associated with cancer and osteolysis

3) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.51 Pain Relevance 0.05

General Comments

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