INT15898

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2011
Negated 7
Speculated 8
Reported most in Abstract
Documents 199
Total Number 209
Disease Relevance 50.89
Pain Relevance 87.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
spinal cord 6
neurons 6
tail 4
brain 4
spinal 3
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 719 100.00 Very High Very High Very High
Kinase C 567 100.00 Very High Very High Very High
Pain 467 100.00 Very High Very High Very High
Spinal cord 454 100.00 Very High Very High Very High
adenocard 67 100.00 Very High Very High Very High
long-term potentiation 478 99.92 Very High Very High Very High
Sciatic nerve 11 99.84 Very High Very High Very High
Morphine 470 99.82 Very High Very High Very High
Hyperalgesia 187 99.80 Very High Very High Very High
nociceptor 149 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 521 100.00 Very High Very High Very High
Nociception 351 100.00 Very High Very High Very High
Injury 160 100.00 Very High Very High Very High
Cough 81 99.92 Very High Very High Very High
Congenital Anomalies 57 99.92 Very High Very High Very High
Cancer 246 99.84 Very High Very High Very High
Hyperalgesia 291 99.80 Very High Very High Very High
Nervous System Injury 58 99.80 Very High Very High Very High
INFLAMMATION 1294 99.74 Very High Very High Very High
Drug Dependence 16 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, cytosolic PKA activity was significantly increased in LSC following morphine treatment for 15 days.
Positive_regulation (increased) of PKA in LSC associated with morphine and spinal cord
1) Confidence 0.70 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 16026714 Disease Relevance 0.22 Pain Relevance 1.80
Furthermore, an increase in cytosolic PKA V(max) was observed in LSC.
Positive_regulation (increase) of PKA V in LSC associated with spinal cord
2) Confidence 0.70 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 16026714 Disease Relevance 0.21 Pain Relevance 1.79
These results suggest that the co-activation of PKC and PKA is needed to elicit naloxone-precipitated withdrawal jumps and enhancement of turnover rate of NA in the frontal cortex in morphine-dependent non-diabetic mice.
Positive_regulation (activation) of PKA in frontal cortex associated with kinase c, diabetes mellitus, noradrenaline, narcan, urological neuroanatomy, withdrawal and morphine
3) Confidence 0.69 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10230858 Disease Relevance 1.09 Pain Relevance 2.12
Furthermore, that PKA affecting AC phosphorylated state and leading to the increase of AC activity suggest that the increase of PKA activities during chronic morphine treatment could lead to the positive feedback regulation in AC/cAMP system and further potentiate the AC/cAMP system, and these may be one of important mechanisms by which chronic opiate induce dependence in target neurons.


Positive_regulation (increase) of PKA in neurons
4) Confidence 0.68 Published 2000 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12903486 Disease Relevance 0 Pain Relevance 0
These findings suggest that the substantial activation of spinal PKC and PKA may differentially contribute to the development of respective chronic pain-like state in mice.
Positive_regulation (activation) of PKA in spinal associated with kinase c and lasting pain
5) Confidence 0.68 Published 2003 Journal Brain Res. Section Abstract Doc Link 14625068 Disease Relevance 0.71 Pain Relevance 0.72
Here we show that transplantation of pre-differentiated ES cells activate both brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) signaling pathways in the host tissue, leading to activation of cAMP/PKA, phosporylation of cofilin and synapsin I, and promoting regenerative growth and neuronal survival.
Positive_regulation (activation) of PKA in neuronal
6) Confidence 0.67 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19138107 Disease Relevance 0.41 Pain Relevance 0.15
The membrane-permeant and phosphodiesterase-resistant cAMP analog 8-Bromoadenosine-3',5'-cyclic monophosphorothioate, Sp-isomer (Sp-8-Br-cAMPS) was utilized for the development of this positive control and this compound produced an increase in PKA activity in several mouse brain regions (i.c.v.) and lumbar spinal cord (i.t.) following its administration.
Positive_regulation (increase) of PKA in spinal cord associated with spinal cord
7) Confidence 0.66 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15913565 Disease Relevance 0 Pain Relevance 0.46
Results from this study indicate that chronic exposure to Delta(9)-THC does not produce an increase in PKA activity in these mouse brain regions or spinal cord.
Positive_regulation (increase) of PKA in spinal cord associated with spinal cord
8) Confidence 0.66 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15913565 Disease Relevance 0 Pain Relevance 0.58
The best-established molecular adaptation to long-term opioid exposure is up-regulation of the cAMP/cAMP-dependent protein kinase (PKA) signaling pathway; this study, therefore, was undertaken to investigate the role of up-regulation of cAMP/PKA signaling pathway in alteration of the mouse hippocampal Na+,K+-ATPase activity.
Positive_regulation (up-regulation) of PKA associated with opioid
9) Confidence 0.64 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0.09 Pain Relevance 0.68
The present data suggest that activation of PKA can preferentially enhance the responses of STT cells to noxious mechanical stimuli without producing an increase in responses to innocuous brushing stimuli.
Positive_regulation (activation) of PKA associated with spinothalamic tract
10) Confidence 0.54 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12091547 Disease Relevance 0.05 Pain Relevance 0.47
PKA in the spinal cord was activated by intra-spinal infusion of forskolin, an activator of adenylate cyclase, by microdialysis.
Positive_regulation (activated) of PKA in spinal cord associated with spinal cord
11) Confidence 0.54 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12091547 Disease Relevance 0.19 Pain Relevance 0.31
Inflammatory mediators through the activation of the protein kinase A (PKA) pathway sensitize primary afferent nociceptors to mechanical, thermal, and osmotic stimuli.
Positive_regulation (activation) of PKA in nociceptors associated with inflammatory mediators and nociceptor
12) Confidence 0.52 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20962237 Disease Relevance 0.47 Pain Relevance 0.46
Finally, the Straub tail score was increased to 1.1-1.6 in PKC and PKA inhibitor-treated tolerant mice, whereas it was totally absent in non-treated animals.
Positive_regulation (increased) of PKA in tail associated with kinase c
13) Confidence 0.49 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 17056270 Disease Relevance 0.17 Pain Relevance 1.35
As illustrated in Figure 2, RGS4 and PKAC?
Positive_regulation (illustrated) of PKA
14) Confidence 0.49 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.36
Thus, RIbeta PKA is necessary for the full expression of tissue injury-evoked (nociceptive) pain but is not required for nerve injury-evoked (neuropathic) pain.
Positive_regulation (necessary) of RIbeta PKA in nerve associated with nociception, pain, nervous system injury, neuropathic pain and injury
15) Confidence 0.49 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9295392 Disease Relevance 1.58 Pain Relevance 1.06
Thus, RIbeta PKA is necessary for the full expression of tissue injury-evoked (nociceptive) pain but is not required for nerve injury-evoked (neuropathic) pain.
Neg (not) Positive_regulation (required) of RIbeta PKA in nerve associated with nociception, pain, nervous system injury, neuropathic pain and injury
16) Confidence 0.49 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9295392 Disease Relevance 1.60 Pain Relevance 1.08
Because the RIbeta subunit is only present in the nervous system, including small diameter trkA receptor-positive dorsal root ganglion cells, we suggest that in inflammatory conditions, RIbeta PKA is specifically required for nociceptive processing in the terminals of small-diameter primary afferent fibers.
Positive_regulation (required) of RIbeta PKA in dorsal root ganglion associated with nociception, ganglion cysts, dorsal root ganglion, inflammation and primary afferent fibers
17) Confidence 0.49 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9295392 Disease Relevance 1.71 Pain Relevance 0.99
However, it appears that tolerance can be dissociated from physical dependence, indicating a role for PKC and PKA to affect antinociception but not those signs mediated through the complex physiological processes of withdrawal.
Positive_regulation (role) of PKA associated with antinociception, kinase c, physical dependence, tolerance and withdrawal
18) Confidence 0.48 Published 2008 Journal Brain Res. Section Abstract Doc Link 18501877 Disease Relevance 0.50 Pain Relevance 1.61
Moreover, the residual persistent currents in these mutant neurons-which are attributable to Nav1.1/1.2 channels-were reduced significantly by PKA activation.
Positive_regulation (activation) of PKA in neurons associated with nav1.1
19) Confidence 0.47 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11264302 Disease Relevance 0 Pain Relevance 0.78
The involvement of AC, PKA or PKCepsilon was observed in the acute hypernociception induced by PGE(2), while PKA or PKCepsilon were continuously activated during the period of persistent hypernociception.
Positive_regulation (activated) of PKA
20) Confidence 0.45 Published 2009 Journal Life Sci. Section Body Doc Link 19896488 Disease Relevance 0 Pain Relevance 0

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