INT158980

Context Info Confidence 0.26 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency plasma 2 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 1 5.00 rheumatoid arthritis 1 5.00 Inflammation 1 5.00 Osteoarthritis 1 5.00 Pain 1 5.00 spinal inflammation 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 2 50.00 Pain 1 5.00 Osteoarthritis 1 5.00 Rheumatoid Arthritis 1 5.00 INFLAMMATION 1 5.00 Low Back Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

CONCLUSION: Pronounced effects of celecoxib on cell viability (reduction), oxygen consumption (stimulation), GLUT-1 mRNA expression (stimulation) and OPG protein secretion (inhibition) in osteoblastic cells were observed only at 50microM-a concentration not reached by therapeutic doses giving plasma concentrations less than 10microM.

Regulation (effects) of Localization (secretion) of OPG in plasma

1) Confidence 0.26 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 19327236 Disease Relevance 0 Pain Relevance 0

General Comments

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