INT15900

Context Info Confidence 0.61 First Reported 1987 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 7 Disease Relevance 2.57 Pain Relevance 0.44

lipid binding (PEBP1) mitochondrion (PEBP1) extracellular space (PEBP1) aging (PEBP1) Golgi apparatus (PEBP1) cytoplasm (PEBP1)

Anatomy Link Frequency hippocampus 1 PEBP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 8 97.64 Opioid 2 97.28 anesthesia 4 65.20 Enkephalin 1 48.84 Neuropeptide 6 25.00

Disease Link Frequency Relevance Heat Benign Prostatic Hypertrophy 4 100.00 Ovarian Cancer 111 99.80 Pressure And Volume Under Development 54 99.32 Learning Disorders 2 99.06 Bardet-biedl Syndrome 21 88.24 Apoptosis 12 80.92 Cancer 75 78.56 Urethral Obstruction 1 75.00 Death 3 70.04 Stress Incontinence 1 38.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The distribution and localization of HCNP-related components and the expression of their mRNAs support the notion that the precursor protein is multifunctional.

Gene_expression (expression) of HCNP

1) Confidence 0.61 Published 2000 Journal Prog. Neurobiol. Section Abstract Doc Link 10622376 Disease Relevance 0.06 Pain Relevance 0.22

Furthermore, several lines of evidence obtained from studies of humans and animal models suggest that certain types of memory and learning disorders are associated with abnormal accumulation and expression of HCNP analogue peptide and/or its precursor protein mRNA in the hippocampus.

Gene_expression (expression) of HCNP in hippocampus associated with learning disorders and hippocampus

2) Confidence 0.55 Published 2000 Journal Prog. Neurobiol. Section Abstract Doc Link 10622376 Disease Relevance 0.10 Pain Relevance 0.15

PEBP1 was detected in 29 out of 30 ascites samples and discriminated ovarian cancer sera from controls (p = 0.02).

Gene_expression (detected) of PEBP1 associated with pressure and volume under development and ovarian cancer

3) Confidence 0.55 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2503970 Disease Relevance 0.50 Pain Relevance 0

Independent evidence for ovarian cancer-specific expression of PEBP1 in patient sera was found by ELISA assays and antibody arrays with anti-PEBP1 antibodies.

Gene_expression (expression) of PEBP1 associated with ovarian cancer

4) Confidence 0.55 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2503970 Disease Relevance 0.49 Pain Relevance 0

Benign prostatic hypertrophy (BPH) produces symptoms that currently can only be treated surgically either by open or endoscopic prostatectomy.

Gene_expression (produces) of Benign prostatic hypertrophy associated with benign prostatic hypertrophy

5) Confidence 0.28 Published 1987 Journal Rofo Section Abstract Doc Link 2446357 Disease Relevance 0.35 Pain Relevance 0.07

In conclusion, using a novel type of biotinylated recombinant antibodies that we call biobodies, we identified complement catabolitic products, EMILIN2, Von Willebrand factor and PEBP1 or a related protein, as candidate markers for ovarian carcinoma.

Gene_expression (products) of PEBP1 associated with ovarian cancer

6) Confidence 0.24 Published 2008 Journal J Transl Med Section Body Doc Link PMC2503970 Disease Relevance 1.06 Pain Relevance 0

Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor.

Gene_expression (overexpression) of kinase inhibitor

7) Confidence 0.03 Published 1991 Journal Mol. Endocrinol. Section Title Doc Link 1770951 Disease Relevance 0 Pain Relevance 0

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