INT159041

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.46
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
adipocyte 1
TUSC5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 96 96.16 Very High Very High Very High
dexamethasone 4 91.12 High High
epidural 2 50.00 Quite Low
spinal stenosis 2 50.00 Quite Low
Central nervous system 4 10.08 Low Low
Potency 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 552 100.00 Very High Very High Very High
Spinal Stenosis 2 74.80 Quite High
Low Back Pain 1 71.92 Quite High
Pain 1 70.20 Quite High
Cancer 20 50.00 Quite Low
Repression 4 21.88 Low Low
Diabetes Mellitus 40 5.00 Very Low Very Low Very Low
Liver Cancer 12 5.00 Very Low Very Low Very Low
Retinoblastoma 4 5.00 Very Low Very Low Very Low
Insulin Resistance 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only one other study has addressed this question, using Zucker fatty rats that lack proper leptin signaling and therefore become extremely obese: Tusc5 mRNA and protein levels were very slightly increased in subcutaneous WAT, unchanged in mesenteric, and yet decreased substantially in epididymal WAT [4].
Negative_regulation (decreased) of Tusc5 mRNA associated with obesity
1) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.99 Pain Relevance 0.04
In a complementary line of research, we examined relationships between obesity and Tusc5, by comparing TUSC5 gene coding variants and its WAT mRNA expression in obese and nonobese human subjects.
Spec (examined) Negative_regulation (comparing) of TUSC5 gene associated with obesity
2) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.76 Pain Relevance 0.14
target gene, but a relationship between Tusc5, obesity, and pharmacological actions of PPAR?
Negative_regulation (relationship) of Tusc5 associated with obesity
3) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.70 Pain Relevance 0.16
We hypothesized that WAT Tusc5 transcript levels would be reduced during states characterized by white adipocyte proliferation, as in obesity, and that the frequency of sequence variation in the TUSC5 coding region would differ between lean versus obese humans.
Negative_regulation (reduced) of WAT Tusc5 in adipocyte associated with obesity
4) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.79 Pain Relevance 0.14
SS showed a more significant reduction in the Roland 5-point pain score and obtained more successful NRS results using the TF technique as compared with the IL technique.
Negative_regulation (reduction) of Roland 5-point
5) Confidence 0.01 Published 2009 Journal Clin J Pain Section Body Doc Link 19333170 Disease Relevance 0.22 Pain Relevance 0

General Comments

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