INT1591

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 1.74
Pain Relevance 7.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
melanocyte 4
brain 2
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 37 100.00 Very High Very High Very High
Dynorphin 13 100.00 Very High Very High Very High
antagonist 10 99.90 Very High Very High Very High
narcan 17 99.76 Very High Very High Very High
opiate 14 99.76 Very High Very High Very High
anesthesia 2 99.76 Very High Very High Very High
agonist 22 99.58 Very High Very High Very High
melanocortin 1 receptor 18 98.44 Very High Very High Very High
medulla 1 97.86 Very High Very High Very High
corticosteroid 3 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Proteinuria 10 99.96 Very High Very High Very High
Disorder Of Lipid Metabolism 2 98.40 Very High Very High Very High
Membranous Glomerulonephritis 12 96.20 Very High Very High Very High
Neuroblastoma 3 86.28 High High
Skin Cancer 2 70.76 Quite High
Stress 4 51.84 Quite High
Increased Venous Pressure Under Development 2 40.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With longer incubation times the specific association of the labeled beta-endorphin with the cells decreased.
Negative_regulation (decreased) of beta-endorphin Binding (association) of
1) Confidence 0.59 Published 1986 Journal Cell Biol. Int. Rep. Section Abstract Doc Link 3017583 Disease Relevance 0 Pain Relevance 0.22
Moreover, potassium (100 mM) decreases the binding of beta-endorphin but does not affect enkephalin binding.
Negative_regulation (decreases) of beta-endorphin Binding (binding) of associated with enkephalin
2) Confidence 0.58 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 217869 Disease Relevance 0 Pain Relevance 0.86
Preliminary results suggest that cells grown in cholesterol-supplemented medium show reduced binding of [3H]met-enkephalin.
Negative_regulation (reduced) of met-enkephalin Binding (binding) of associated with enkephalin
3) Confidence 0.57 Published 1984 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6099592 Disease Relevance 0.23 Pain Relevance 0.78
Reduction of disulfide bonds in human melanocortin 1 receptor (hMC1R) with increasing concentrations of DTT (dithiothreitol) resulted in a decrease in the binding of [125I]-ACTH (adrenocorticotropic hormone, L-isomer) in an uniphasic manner and a decrease in [125I]-NDP-MSH ([Nle(4),D-Phe(7)]-alpha-melanocyte stimulating hormone; D-isomer) binding in a biphasic manner.
Negative_regulation (decrease) of ACTH Binding (binding) of in melanocyte associated with melanocortin 1 receptor
4) Confidence 0.56 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11237737 Disease Relevance 0 Pain Relevance 0.25
The ability of various enkephalin analogs, as well as opiate agonists and antagonists, to inhibit the binding of beta-endorphin clearly demonstrates that this peptide can bind to opiate receptors.
Negative_regulation (inhibit) of beta-endorphin Binding (binding) of associated with antagonist, agonist, opiate and enkephalin
5) Confidence 0.43 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 217869 Disease Relevance 0 Pain Relevance 0.82
The mutants Asp84Glu and Asp294His showed a much lower response to alpha-MSH in cAMP and a slightly impaired ability to bind alpha-MSH, and the Val92Met mutant bound alpha-MSH with 100-fold lower affinity as compared with the wild-type.
Negative_regulation (impaired) of alpha-MSH Binding (bind) of
6) Confidence 0.43 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15482480 Disease Relevance 0.14 Pain Relevance 0.12
Influence on memory of posttraining or pre-test injections of ACTH, vasopressin, epinephrine, and beta-endorphin, and their interaction with naloxone.
Negative_regulation (posttraining) of ACTH Binding (injections) of associated with narcan
7) Confidence 0.42 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 2994140 Disease Relevance 0 Pain Relevance 0.30
Influence on memory of posttraining or pre-test injections of ACTH, vasopressin, epinephrine, and beta-endorphin, and their interaction with naloxone.
Negative_regulation (posttraining) of beta-endorphin Binding (interaction) of associated with narcan
8) Confidence 0.42 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 2994140 Disease Relevance 0 Pain Relevance 0.31
[Anesthetic management of a patient with adrenocorticotropic hormone (ACTH) deficiency].
Negative_regulation (deficiency) of ACTH Binding (management) of associated with anesthesia
9) Confidence 0.42 Published 1994 Journal Masui Section Title Doc Link 7837411 Disease Relevance 0 Pain Relevance 0.25
Acetylated beta-endorphin-(1-31) displayed a biphasic curve when competing with 5 pM [125I]-Tyr27 human beta-endorphin-(1-31) specific binding, the first step (20 to 30% of the binding) was abolished with an apparent IC50 of 0.35 nM, and the rest with an IC50 of 200 nM.
Negative_regulation (abolished) of beta-endorphin Binding (binding) of
10) Confidence 0.37 Published 1991 Journal Life Sci. Section Abstract Doc Link 2008158 Disease Relevance 0 Pain Relevance 0.77
Reduction of disulfide bonds in human melanocortin 1 receptor (hMC1R) with increasing concentrations of DTT (dithiothreitol) resulted in a decrease in the binding of [125I]-ACTH (adrenocorticotropic hormone, L-isomer) in an uniphasic manner and a decrease in [125I]-NDP-MSH ([Nle(4),D-Phe(7)]-alpha-melanocyte stimulating hormone; D-isomer) binding in a biphasic manner.
Negative_regulation (decrease) of adrenocorticotropic hormone Binding (binding) of in melanocyte associated with melanocortin 1 receptor
11) Confidence 0.35 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11237737 Disease Relevance 0 Pain Relevance 0.25
Presynaptic inhibitory effect of Met-enkephalin on [14C] acetylcholine release from the myenteric plexus and its interaction with muscarinic negative feedback inhibition.
Negative_regulation (effect) of Met-enkephalin Binding (interaction) of associated with enkephalin
12) Confidence 0.29 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6747844 Disease Relevance 0 Pain Relevance 0.37
Presynaptic inhibitory effect of Met-enkephalin on [14C] acetylcholine release from the myenteric plexus and its interaction with muscarinic negative feedback inhibition.
Negative_regulation (inhibition) of Met-enkephalin Binding (interaction) of associated with enkephalin
13) Confidence 0.29 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6747844 Disease Relevance 0 Pain Relevance 0.38
Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown.
Negative_regulation (reduces) of ACTH Binding (treatment) of associated with proteinuria
14) Confidence 0.15 Published 2010 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 20507942 Disease Relevance 0.69 Pain Relevance 0.17
Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown.
Negative_regulation (reduces) of adrenocorticotropic hormone Binding (treatment) of associated with proteinuria
15) Confidence 0.13 Published 2010 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 20507942 Disease Relevance 0.69 Pain Relevance 0.17
The fractions were assayed for the ability to stimulate corticosterone production in isolated rat adrenal decapsular (zona fasciculata, zona reticularis and medulla) cells, to displace D-ala2-D-leu5-(tyrosyl-3,5-3H) enkephalin from binding to rat brain membranes, and to inhibit 125I-human beta-endorphin from binding to its antibodies. 4.
Negative_regulation (inhibit) of beta-endorphin Binding (binding) of in brain associated with medulla and enkephalin
16) Confidence 0.09 Published 1990 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 1971555 Disease Relevance 0 Pain Relevance 0.35
Reduced behavioral effectiveness of ACTH(1-24) after a second administration: interaction with opiates.
Negative_regulation (Reduced) of ACTH Binding (interaction) of associated with opiate
17) Confidence 0.09 Published 1978 Journal Neurosci. Lett. Section Title Doc Link 19605229 Disease Relevance 0 Pain Relevance 0.40
MSH binding was lost independently in lemur and New World monkey lineages, whereas high basal levels of MC1R activity occur in lemurs and some New World monkeys and Old World monkeys.
Negative_regulation (lost) of MSH Binding (binding) of associated with melanocortin 1 receptor
18) Confidence 0.08 Published 2007 Journal Mol. Biol. Evol. Section Abstract Doc Link 17609536 Disease Relevance 0 Pain Relevance 0.57
The inhibitory potencies of adrenocorticotropic hormone, peptide E, and dynorphin A were virtually identical for the formation of the two products.
Negative_regulation (potencies) of adrenocorticotropic hormone Binding (formation) of associated with dynorphin
19) Confidence 0.02 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2872272 Disease Relevance 0 Pain Relevance 0.56

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