INT159102

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.28
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
ECM 3
embryo 1
decidua 1
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 56 99.36 Very High Very High Very High
metalloproteinase 139 99.20 Very High Very High Very High
Dismenorea 10 95.40 Very High Very High Very High
cytokine 43 87.20 High High
chemokine 21 86.64 High High
isoflurane 1 83.36 Quite High
anesthesia 7 82.48 Quite High
long-term potentiation 12 63.00 Quite High
adenocard 15 19.60 Low Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 7 98.64 Very High Very High Very High
Adhesions 13 96.76 Very High Very High Very High
Dysmenorrhea 10 95.40 Very High Very High Very High
Fatigue 4 94.08 High High
Stress 3 85.92 High High
Myocardial Infarction 2 75.00 Quite High
Apoptosis 10 69.36 Quite High
Reprotox - General 1 6 68.40 Quite High
Adult Respiratory Distress Syndrome 20 57.24 Quite High
Sprains And Strains 3 48.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, we examined ECM components and regulators in a rat postinfarction model of CHF.
Spec (examined) Regulation (regulators) of ECM in ECM associated with heart rate under development
1) Confidence 0.16 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19339678 Disease Relevance 0.67 Pain Relevance 0.23
It has been proposed that ANX4 could affect the mobilization of different substrates involved in the regulation of the ECM.
Regulation (regulation) of ECM
2) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.03
can have a noxious impact on the success of implantation and progression of pregnancy, at least in part by deregulating the turnover of the ECM in the decidua.
Regulation (deregulating) of ECM in decidua
3) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.16 Pain Relevance 0.25
A drawback, however, is that it is difficult to independently control substrate stiffness and ECM biochemistry in these 3D systems.
Neg (independently) Regulation (control) of ECM
4) Confidence 0.12 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2687114 Disease Relevance 0.20 Pain Relevance 0
silences or decreases the expression of genes related with the systems aforementioned, it also could affect tissue remodelling by directly modifying the proteases involved in this process, or indirectly by affecting the ECM turnover and degradation, important in the accumulation of a spongy mass of tissue around each embryo during decidualization [45].
Regulation (affecting) of ECM in embryo
5) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
These properties suggest that acidic Cap is functionally distinct from basic Cap and could affect the ECM in a different manner [29].
Regulation (affect) of ECM
6) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
in primary decidual cells are genes involved in the regulation of the ECM.
Regulation (regulation) of ECM in ECM
7) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
ECM molecules by interfering with MMP activity appears to prevent
Regulation (molecules) of ECM associated with metalloproteinase
8) Confidence 0.05 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0 Pain Relevance 0.45
Matrix metalloproteinase (MMP) activity is responsible for transient alterations in the ECM that may be prerequisite to hippocampal-dependent learning.
Regulation (alterations) of ECM in ECM associated with metalloproteinase
9) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Abstract Doc Link PMC1838960 Disease Relevance 0.10 Pain Relevance 0.40
Taken together, these findings suggest that overdistension due to MV leads to an early response of the ECM.
Regulation (response) of ECM
10) Confidence 0.02 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.14 Pain Relevance 0

General Comments

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