INT159113

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.85
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MT1F) cytoplasm (MT1F)
Anatomy Link Frequency
plasma 1
blood 1
MT1F (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 7 92.88 High High
Inflammation 23 77.52 Quite High
Arthritis 1 75.12 Quite High
tolerance 1 33.12 Quite Low
transdermal 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 2 95.44 Very High Very High Very High
Apoptosis 7 94.56 High High
Disease 19 93.80 High High
Pain 3 92.88 High High
Bone Cancer 1 91.64 High High
Proteinuria 3 88.68 High High
Death 5 88.08 High High
Necrosis 5 87.52 High High
Toxicity 60 84.44 Quite High
Acanthosis 1 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, the toxicokinetics and toxicodynamics of Cd were described including its binding to the protein metallothionein.
metallothionein Binding (binding) of
1) Confidence 0.42 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19341754 Disease Relevance 0.53 Pain Relevance 0.09
Once taken up by the blood, the majority of cadmium is transported bound to proteins, such as Albumin and Metallothionein.
Metallothionein Binding (bound) of in blood
2) Confidence 0.19 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1578573 Disease Relevance 0.47 Pain Relevance 0
In human serum, cadmium usually exists as a complex with metallothionein and other proteins.
metallothionein Binding (complex) of
3) Confidence 0.08 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1332665 Disease Relevance 0 Pain Relevance 0
19 mol estimated in plasma, by binding to ceruloplasmin and metallothionein [24].
metallothionein Binding (binding) of in plasma
4) Confidence 0.05 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2945467 Disease Relevance 0.54 Pain Relevance 0.13
Mercurous and mercuric ions impart their toxicological effects mainly through molecular interactions with sulfhydryl groups on various molecules like GSH, metallothionein (MT) and albumin [183–187].
metallothionein Binding (interactions) of
5) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2922724 Disease Relevance 0.30 Pain Relevance 0

General Comments

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