INT159115

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 1.33
Pain Relevance 5.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnb2l1) cytoskeleton (Gnb2l1) nucleus (Gnb2l1)
cell cycle (Gnb2l1) cytoplasm (Gnb2l1)
Anatomy Link Frequency
striatum 6
dentate gyrus 2
frontal cortex 2
hippocampus 2
Gnb2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 22 99.84 Very High Very High Very High
Morphine 46 99.46 Very High Very High Very High
Nucleus accumbens 12 99.20 Very High Very High Very High
Pyramidal cell 2 95.92 Very High Very High Very High
addiction 6 90.88 High High
opiate 2 63.48 Quite High
Neuropeptide 10 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 100.00 Very High Very High Very High
Drug Dependence 4 90.88 High High
Opiate Addiction 2 63.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Negative_regulation (decreased) of Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
1) Confidence 0.42 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.95
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Negative_regulation (decreased) of Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
2) Confidence 0.42 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.95
The expression of RACK1 and CREB protein was negative in CA1, CA3 and DG of hippocampus.
Negative_regulation (negative) of Gene_expression (expression) of RACK1 in hippocampus associated with hippocampus
3) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.14 Pain Relevance 0.87
The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus.
Negative_regulation (positive) of Gene_expression (expression) of RACK1 in dentate gyrus associated with pyramidal cell, hippocampus and morphine
4) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.23 Pain Relevance 0.93
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Negative_regulation (decreased) of in frontal cortex Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
5) Confidence 0.14 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.95
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Negative_regulation (decreased) of in frontal cortex Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
6) Confidence 0.14 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.95

General Comments

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