INT159116

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Context Info
Confidence 0.77
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.79
Pain Relevance 9.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnb2l1) cytoskeleton (Gnb2l1) nucleus (Gnb2l1)
cell cycle (Gnb2l1) cytoplasm (Gnb2l1)
Anatomy Link Frequency
frontal cortex 3
striatum 2
hippocampus 2
dentate gyrus 1
prefrontal 1
Gnb2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 42 99.84 Very High Very High Very High
Morphine 83 99.48 Very High Very High Very High
Nucleus accumbens 21 99.20 Very High Very High Very High
member 8 2 97.68 Very High Very High Very High
Pyramidal cell 4 94.36 High High
addiction 12 90.88 High High
monoamine 2 86.40 High High
opiate 4 63.48 Quite High
opioid receptor 2 60.16 Quite High
Neuropeptide 18 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 21 100.00 Very High Very High Very High
Reprotox - General 1 94 93.96 High High
Drug Dependence 8 90.88 High High
Cancer 14 81.04 Quite High
Opiate Addiction 4 63.88 Quite High
Death 7 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Metastasis 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Recurrence 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study is to investigate the effect of overexpression of RACK1 on the conditioned place preference (CPP) and the level of p-ERK in morphine reexposure mice.
Gene_expression (overexpression) of RACK1 associated with morphine
1) Confidence 0.77 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.68
The expression of RACK1 and CREB protein was negative in CA1, CA3 and DG of hippocampus.
Gene_expression (expression) of RACK1 in hippocampus associated with hippocampus
2) Confidence 0.70 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.14 Pain Relevance 0.87
These findings suggest that morphine reward can influence the expression of RACK1 in mouse hippocampus and prefrontal cortex through regulating CREB transcription.
Gene_expression (expression) of RACK1 in hippocampus associated with hippocampus and morphine
3) Confidence 0.70 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.13 Pain Relevance 0.84
The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus.
Gene_expression (expression) of RACK1 in dentate gyrus associated with pyramidal cell, hippocampus and morphine
4) Confidence 0.70 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.23 Pain Relevance 0.92
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
5) Confidence 0.67 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.23 Pain Relevance 0.93
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
6) Confidence 0.67 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.94
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Gene_expression (levels) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
7) Confidence 0.67 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
In this study we demonstrated that RACK1 decreased p-ERK and erased CPP during reexposure of morphine and there was no an effect in reexposure saline mice.
Gene_expression (decreased) of RACK1 associated with morphine
8) Confidence 0.67 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.22 Pain Relevance 0.92
The gene expression trends of GAS5 [125], GNB2L1 [126], MT-ND3, NKX3-1 [127], PCGEM1 [128], PTGFR [129], STEAP1 [130], and TMEM30A [131] were in agreement with the presence of proliferating cells in CRPC.
Gene_expression (expression) of GNB2L1 in ND3 associated with reprotox - general 1
9) Confidence 0.52 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.57 Pain Relevance 0.17
These findings suggest that morphine reward can influence the expression of RACK1 in mouse hippocampus and prefrontal cortex through regulating CREB transcription.
Gene_expression (expression) of RACK1 in prefrontal associated with hippocampus and morphine
10) Confidence 0.24 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.13 Pain Relevance 0.84
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Gene_expression (level) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
11) Confidence 0.23 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.94
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Gene_expression (level) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
12) Confidence 0.23 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.23 Pain Relevance 0.93

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