INT159118

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.37
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
dentate gyrus 1
hippocampus 1
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 84 98.68 Very High Very High Very High
Hippocampus 15 98.56 Very High Very High Very High
Morphine 10 98.28 Very High Very High Very High
Pyramidal cell 2 95.04 Very High Very High Very High
addiction 6 89.92 High High
c fibre 28 83.60 Quite High
opiate 2 62.52 Quite High
spinal dorsal horn 50 61.08 Quite High
Dorsal horn neuron 1 50.00 Quite Low
nMDA receptor antagonist 3 28.12 Quite Low
Disease Link Frequency Relevance Heat
Drug Dependence 4 89.92 High High
Opiate Addiction 2 62.92 Quite High
Hyperalgesia 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus.
Protein_catabolism (protein) of CREB in dentate gyrus associated with pyramidal cell, hippocampus and morphine
1) Confidence 0.61 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.23 Pain Relevance 0.92
The expression of RACK1 and CREB protein was negative in CA1, CA3 and DG of hippocampus.
Protein_catabolism (protein) of CREB in hippocampus associated with hippocampus
2) Confidence 0.61 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.14 Pain Relevance 0.86
Activation of CaMKII, ERK and CREB proteins and expression of c-Fos following HFS were prevented by either EphB2-Fc or targeted mutation of the EphB1 receptor
Protein_catabolism (proteins) of CREB
3) Confidence 0.54 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.39

General Comments

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