INT159119

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.60
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
hippocampus 3
dentate gyrus 2
neurons 2
bars 1
neuronal 1
Car1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 386 100.00 Very High Very High Very High
Glutamate 28 100.00 Very High Very High Very High
nMDA receptor 64 99.88 Very High Very High Very High
ischemia 7 98.80 Very High Very High Very High
Morphine 10 97.96 Very High Very High Very High
Pyramidal cell 73 96.20 Very High Very High Very High
antagonist 53 91.28 High High
addiction 8 88.88 High High
Pain 16 86.24 High High
GABAergic 11 86.04 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 251 100.00 Very High Very High Very High
Neurodegenerative Disease 145 100.00 Very High Very High Very High
Disease 59 99.46 Very High Very High Very High
Tachycardia 2 99.24 Very High Very High Very High
Anxiety Disorder 147 98.84 Very High Very High Very High
Cv Unclassified Under Development 4 98.80 Very High Very High Very High
Epilepsy 20 98.60 Very High Very High Very High
Cognitive Disorder 89 98.20 Very High Very High Very High
Shock 119 97.40 Very High Very High Very High
Sclerosis 2 96.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a substantial and highly significant loss of PV-interneurons in aged hippocampus (Fig. 4), with the CA2-3 region being the most affected (20% decrease for CA1, main effect of age: F(1,17)?
Negative_regulation (decrease) of CA1 in hippocampus associated with hippocampus
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.30 Pain Relevance 0.24
Dexmedetomidine induced a postconditioning effect in the CA1 (but not dentate gyrus) subfield area, which was significantly reduced by modulators of the focal adhesion and the extracellular-regulated kinases pathways.
Negative_regulation (reduced) of CA1 in dentate gyrus
2) Confidence 0.27 Published 2010 Journal Anesthesiology Section Body Doc Link 20098140 Disease Relevance 0.07 Pain Relevance 0
Hippocampal sclerosis, a pattern of neuronal loss in vulnerable mesial structures of the temporal lobe, is found in about 70% of TLE patients [1], [2], and is characterized by severe segmental neuronal loss in the hippocampal subfields CA1, CA3, and the hilar region [3], [4].
Negative_regulation (loss) of CA1 in temporal lobe associated with epilepsy and sclerosis
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 1.71 Pain Relevance 0.03
5 measurements/stimulus intensity and animal), the slope of fEPSPs (in mV/s) evoked in the CA1 area by the first pulse increased steadily with current strength, to asymptotic values (at ?
Negative_regulation (evoked) of CA1 associated with tachycardia
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2763346 Disease Relevance 0.25 Pain Relevance 0.03
This suggests that GluR2 deletion in CA1 selectively impairs NMDAR-dependent learning.
Negative_regulation (deletion) of CA1
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.18
In the controls we observed no loss of GluR2 in dorsal hippocampus CA1 at 8 weeks compared to 6 weeks of age (p>.05).
Neg (no) Negative_regulation (loss) of CA1 in hippocampus CA1 associated with hippocampus
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.22
These data demonstrate that deletion of GluR2 in the CA1 region impairs long-term memory for context fear.
Negative_regulation (deletion) of CA1 associated with anxiety disorder
7) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 1.04 Pain Relevance 0
These results demonstrate that the loss of GluR2 in CA1 selectively impairs context fear (see Text S1 for a more detailed discussion).
Negative_regulation (loss) of CA1 associated with anxiety disorder
8) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 1.14 Pain Relevance 0.26
The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus.
Negative_regulation (positive) of CA1 in dentate gyrus associated with pyramidal cell, hippocampus and morphine
9) Confidence 0.23 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.23 Pain Relevance 0.93
The expression of RACK1 and CREB protein was negative in CA1, CA3 and DG of hippocampus.
Negative_regulation (negative) of CA1 in hippocampus associated with hippocampus
10) Confidence 0.23 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.13 Pain Relevance 0.86
Therefore, these results indicate that the absence of dysbindin also impairs the kinetics of evoked glutamate release in hippocampal CA1.


Negative_regulation (impairs) of CA1 associated with glutamate
11) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.24 Pain Relevance 0.27
These results indicate that both NR2A and NR2B-containing NMDA receptors were impaired in transgenic CA1 hippocampal neurons.


Negative_regulation (impaired) of CA1 in neurons associated with targeted disruption and nmda receptor
12) Confidence 0.20 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.16 Pain Relevance 0.53
CREB inactivation specifically in area CA1 of the hippocampus was also shown to impair object recognition memory (Pittenger et al., 2002).
Negative_regulation (inactivation) of CA1 in hippocampus associated with cognitive disorder and hippocampus
13) Confidence 0.15 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.25 Pain Relevance 0.11
(C): Quantification revealed that infusion of FS-288 in KA-injected animals (n = 10, black bars) inhibited neurogenesis in the DG, CA3, and CA1, whereas infusion of activin A in KA-injected animals (n = 10, gray bars) had no effect on the number of new neurons compared to KA-injected controls (n = 11, white bars).
Negative_regulation (inhibited) of CA1 in bars associated with neurodegenerative disease
14) Confidence 0.12 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.39 Pain Relevance 0.11
A similar mouse line with the M233T/L235P mutations knocked in the PS1 gene (APPSLPS1ki) develops a very aggressive form of the disease with a prominent neuronal loss in the CA1 sector [48].
Negative_regulation (loss) of CA1 in neuronal associated with disease
15) Confidence 0.11 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.37 Pain Relevance 0
SNCA levels in the right CA1 (Figure 3A), the site of injection, remained noticeably reduced when compared to the uninjected control side through three weeks post-infusion.
Negative_regulation (reduced) of CA1
16) Confidence 0.09 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.08 Pain Relevance 0.10
We were able to use this approach to show that reducing TRPM7 currents in CA1 neurons of the rat provides substantial protection against the loss of CA1 neurons in a model of global ischemia [5,7].
Negative_regulation (loss) of CA1 in neurons associated with ischemia
17) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.24 Pain Relevance 0.12

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