INT159121

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.79
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map3k1) cytoplasm (Map3k1)
Map3k1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 99.58 Very High Very High Very High
Morphine 10 99.36 Very High Very High Very High
Spinal cord 34 98.84 Very High Very High Very High
addiction 9 98.64 Very High Very High Very High
opiate 2 98.36 Very High Very High Very High
Neuropathic pain 37 96.48 Very High Very High Very High
Lasting pain 2 94.12 High High
dexamethasone 144 92.20 High High
allodynia 5 88.28 High High
Hyperalgesia 2 87.84 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 10 100.00 Very High Very High Very High
Infection 228 98.64 Very High Very High Very High
Drug Dependence 4 98.64 Very High Very High Very High
Opiate Addiction 2 98.36 Very High Very High Very High
Apoptosis 80 98.08 Very High Very High Very High
Nervous System Injury 16 97.60 Very High Very High Very High
Neuropathic Pain 49 96.48 Very High Very High Very High
Breast Cancer 14 95.92 Very High Very High Very High
Pain 9 94.12 High High
Cytomegalovirus Infection 15 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M.MR virus enhanced MEKK1 activation of the NF-?
Positive_regulation (activation) of MEKK1
1) Confidence 0.45 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.58 Pain Relevance 0
M-expressing viruses strongly inhibited MEKK1 activation of the NF-?
Positive_regulation (activation) of MEKK1
2) Confidence 0.45 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.62 Pain Relevance 0
This activation synergized with MEKK1 activation to further enhance NF-?
Positive_regulation (activation) of MEKK1
3) Confidence 0.33 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.48 Pain Relevance 0
RACK1, the protein receptor for activated C kinase 1, is a multifunctional scaffolding protein known to be a key regulator of various signaling cascades in the CNS.
Positive_regulation (activated) of kinase 1
4) Confidence 0.05 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.26 Pain Relevance 0.50
Protein receptor for activated C kinase 1 is involved in morphine reward in mice.
Positive_regulation (activated) of kinase 1 associated with neuropeptide and morphine
5) Confidence 0.05 Published 2009 Journal Neuroscience Section Title Doc Link 19341783 Disease Relevance 0.25 Pain Relevance 0.65
Here we tested the third strategy in adult mice in which the PTEN-induced putative kinase 1 (PINK1) gene, a Parkinson disease (PD)-associated gene, was targeted.
Positive_regulation (induced) of kinase 1 associated with parkinson's disease
6) Confidence 0.04 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.92 Pain Relevance 0
Upregulation of casein kinase 1?
Positive_regulation (Upregulation) of kinase 1
7) Confidence 0.04 Published 2009 Journal Mol Pain Section Title Doc Link PMC2804670 Disease Relevance 1.22 Pain Relevance 0.94
Here we tested the third strategy in adult mice in which the PTEN-induced putative kinase 1 (PINK1) gene, a Parkinson disease (PD)-associated gene, was targeted.
Positive_regulation (targeted) of kinase 1 associated with parkinson's disease
8) Confidence 0.03 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.95 Pain Relevance 0
For inhibition of apoptosis a functional glucocorticoid receptor (GR) is required and association with the transcriptional induction of survival molecules like serum and GC-inducible protein kinase-1 (SGK-1) and mitogen-activated protein kinase phosphatase-1 (MKP-1) is suggested in human established breast cancer cell lines [15].
Positive_regulation (inducible) of kinase-1 associated with breast cancer and apoptosis
9) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.73 Pain Relevance 0.25
For inhibition of apoptosis a functional glucocorticoid receptor (GR) is required and association with the transcriptional induction of survival molecules like serum and GC-inducible protein kinase-1 (SGK-1) and mitogen-activated protein kinase phosphatase-1 (MKP-1) is suggested in human established breast cancer cell lines [15].
Positive_regulation (induction) of kinase-1 associated with breast cancer and apoptosis
10) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.77 Pain Relevance 0.26

General Comments

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