INT159122

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.20
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnb2l1) cytoskeleton (Gnb2l1) nucleus (Gnb2l1)
cell cycle (Gnb2l1) cytoplasm (Gnb2l1)
Anatomy Link Frequency
striatum 2
frontal cortex 2
nucleus accumbens 1
hippocampus 1
Gnb2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 19 99.84 Very High Very High Very High
Morphine 59 99.52 Very High Very High Very High
Nucleus accumbens 18 98.96 Very High Very High Very High
cytokine 3 96.44 Very High Very High Very High
addiction 3 93.72 High High
Pyramidal cell 1 83.76 Quite High
opiate 1 66.32 Quite High
Inflammation 4 42.96 Quite Low
Neuropeptide 13 25.00 Low Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 99.64 Very High Very High Very High
Drug Dependence 2 93.72 High High
Stress 19 92.32 High High
Alzheimer's Dementia 2 89.52 High High
Apoptosis 63 70.56 Quite High
Opiate Addiction 1 66.72 Quite High
Death 5 57.16 Quite High
Adhesions 1 56.56 Quite High
INFLAMMATION 5 42.96 Quite Low
Hepatotoxicity 2 30.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
1) Confidence 0.69 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.44
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Positive_regulation (increased) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
2) Confidence 0.46 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.93
Chronic administration of morphine made the expression of RACK1 and CREB mRNA increase in hippocampus and prefrontal cortex.
Positive_regulation (increase) of RACK1 associated with hippocampus and morphine
3) Confidence 0.45 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.24 Pain Relevance 0.89
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of RACK1 in nucleus accumbens associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
4) Confidence 0.24 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.44
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of RACK1 in hippocampus associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
5) Confidence 0.24 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.44
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
6) Confidence 0.24 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.44
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Positive_regulation (increased) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
7) Confidence 0.16 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.93
FAN, RACK-1 and caveolin-1) have been shown to trigger nSMase activation [5], [6].
Positive_regulation (activation) of RACK-1
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.71 Pain Relevance 0.09

General Comments

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