INT159126

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.76
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SUGT1) mitosis (SUGT1)
Anatomy Link Frequency
immune cells 1
SUGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 100.00 Very High Very High Very High
Catechol-O-methyltransferase 29 99.48 Very High Very High Very High
Endogenous opioid 2 99.42 Very High Very High Very High
opioid receptor 4 89.64 High High
Potency 1 86.36 High High
depression 8 52.00 Quite High
Dopamine 3 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Nortriptyline 2 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 62 97.04 Very High Very High Very High
Coronary Artery Disease 53 96.48 Very High Very High Very High
Disease 12 88.36 High High
Necrosis 1 75.24 Quite High
Cancer 2 74.88 Quite High
Nicotine Addiction 1 55.60 Quite High
Hypertension 1 54.20 Quite High
Depression 11 52.00 Quite High
Adhesions 4 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the sensitive endogenous opioid system in carriers of the G allele may suppress proinflammatory cytokine secretion from peripheral immune cells; consequently, it may influence the health perception.
Localization (secretion) of allele in immune cells associated with endogenous opioid and cytokine
1) Confidence 0.06 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 19341791 Disease Relevance 0.20 Pain Relevance 0.51
No significant association of gender with genotype or allele frequency of DRD2 and COMT was observed in either sample.
Localization (frequency) of allele associated with catechol-o-methyltransferase
2) Confidence 0.06 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.26
Put together, therefore, it can be inferred that the presence of the mutant R allele of the E-selectin gene greatly increases the likelihood of patients with DM2 acquiring CAD.
Localization (presence) of allele associated with coronary artery disease and diabetes mellitus
3) Confidence 0.04 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.56 Pain Relevance 0.04

General Comments

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