INT159127

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 49
Total Number 54
Disease Relevance 16.91
Pain Relevance 12.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nps) molecular_function (Nps)
Anatomy Link Frequency
brain 2
neuronal 2
ventral 2
grids 1
liver 1
Nps (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 1818 100.00 Very High Very High Very High
Neuropeptide 69 100.00 Very High Very High Very High
Pain 21 100.00 Very High Very High Very High
Analgesic 16 100.00 Very High Very High Very High
antinociception 9 100.00 Very High Very High Very High
narcan 9 100.00 Very High Very High Very High
Antinociceptive 9 99.96 Very High Very High Very High
Calcitonin gene-related peptide 1 99.96 Very High Very High Very High
dorsal root ganglion 4 99.64 Very High Very High Very High
medulla 18 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 64 100.00 Very High Very High Very High
Anxiety Disorder 867 99.84 Very High Very High Very High
Targeted Disruption 10 99.78 Very High Very High Very High
Ganglion Cysts 4 99.64 Very High Very High Very High
Cancer 540 99.52 Very High Very High Very High
Lymphatic System Cancer 15 99.48 Very High Very High Very High
Pressure And Volume Under Development 188 99.12 Very High Very High Very High
Brain Tumor 50 98.80 Very High Very High Very High
Cardiovascular Disease 96 98.52 Very High Very High Very High
Anaemia 3 98.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, NPS receptors are also expressed in lower layers of the PC, indicating that they may form a functional NPS-responsive unit with the EPN/PC area.
Gene_expression (expressed) of NPS
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0.05 Pain Relevance 0.30
Several lines of evidence suggest the endopiriform nucleus as the source of this NPS dependent modulation: the NPS receptor is expressed most abundantly in this region [6], direct projections from the piriform cortex and endopiriform nucleus to the BLA have been described [14]–[16], and stimulation of the ventral endopiriform nucleus can evoke excitatory postsynaptic potentials in the BLA [13].
Gene_expression (expressed) of NPS receptor in ventral associated with amygdala
2) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0 Pain Relevance 0.45
These results revealed that NPS could produce antinociception through NPS receptor, but not opioid receptor, and NPS-NPSR system could be a potential target for developing new analgesic drugs.
Gene_expression (produce) of NPS associated with antinociception, analgesic and opioid receptor
3) Confidence 0.68 Published 2009 Journal Regul. Pept. Section Abstract Doc Link 19345242 Disease Relevance 0.37 Pain Relevance 1.29
Although it remains to be investigated whether the NPS expressing neurons in the locus coeruleus area indeed project to the EPN and whether or not they show similar functional properties as their noradrenergic counterparts, it is striking that increases of inhibition in the BLA recorded in vivo upon locus coeruleus stimulation could only partly be blocked by the beta-adreno receptor antagonist timolol [29].
Gene_expression (expressing) of NPS in locus coeruleus associated with antagonist, locus ceruleus and amygdala
4) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0.35 Pain Relevance 0.49
In the brain, NPS is expressed in three brainstem nuclei (locus coeruleus, lateral parabrachial nucleus and principle trigeminal nucleus) as well as a few scattered neurons in the medial amygdala and dorsomedial hypothalamus.
Gene_expression (expressed) of NPS in nucleus associated with medulla, locus ceruleus, amygdala and parabrachial
5) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0.19 Pain Relevance 0.38
Likewise, the NPS receptor shows a distinct expression pattern across various cortical and subcortical regions, hence indicating the existence of a highly specialized NPS circuitry.
Gene_expression (expression) of NPS receptor
6) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0.28 Pain Relevance 0.52
Although they tend to be well correlated, absolute levels of the two NPs are not interchangeable, and it is helpful for clinicians to understand the differences and nuances between them.
Gene_expression (levels) of NPs
7) Confidence 0.59 Published 2010 Journal Curr Cardiovasc Risk Rep Section Body Doc Link PMC2894089 Disease Relevance 1.02 Pain Relevance 0
These results revealed that NPS could produce antinociception through NPS receptor, but not opioid receptor, and NPS-NPSR system could be a potential target for developing new analgesic drugs.
Gene_expression (produce) of NPS associated with antinociception, analgesic and opioid receptor
8) Confidence 0.59 Published 2009 Journal Regul. Pept. Section Abstract Doc Link 19345242 Disease Relevance 0.37 Pain Relevance 1.30
Neuropeptide S produces antinociceptive effects at the supraspinal level in mice.
Gene_expression (produces) of Neuropeptide S associated with neuropeptide and antinociceptive
9) Confidence 0.59 Published 2009 Journal Regul. Pept. Section Title Doc Link 19345242 Disease Relevance 0.50 Pain Relevance 1.26
Here we confirmed the effectiveness of this carrier for brain targeting, comparing the effect obtained by the administration of loperamide-loaded NPs with the effect of an intracerebroventricular administration of the drug; moreover, the biodistribution of these NPs showed a localization into the CNS in a quantity about two orders of magnitude greater than that found with the other known NP drug carriers.
Gene_expression (biodistribution) of NPs in CNS associated with central nervous system and intracerebroventricular
10) Confidence 0.58 Published 2009 Journal Nanomedicine Section Abstract Doc Link 19341816 Disease Relevance 0.07 Pain Relevance 0.22
The NPs even crossed synapses in the olfactory glomeruli and reached mitral cell dendrites within 1 hr after intranasal instillation.
Gene_expression (crossed) of NPs in synapses
11) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.08 Pain Relevance 0.10
Studies of ultrathin sections of CB-treated neuronal networks in TEM demonstrated the presence of the NPs in the cells (Figure 2).
Gene_expression (presence) of NPs in neuronal
12) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.09 Pain Relevance 0
TiO2 NPs caused severe inhibition of the general electrical network activity, with 1 ?
Gene_expression (caused) of NPs
13) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
We tested TiO2 NPs at concentrations ranging from 0.01 to 300 ?
Gene_expression (tested) of NPs
14) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
We investigated the effects of the different NPs at concentrations of 0.5, 5, and 10 ?
Spec (investigated) Gene_expression (effects) of NPs
15) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.10 Pain Relevance 0
Smaller NPs cross the BBB more easily than do larger NPs.
Gene_expression (cross) of NPs
16) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
We tested Fe2O3 NPs for neurotoxic potential in concentrations of 0.1–100 ?
Gene_expression (tested) of NPs
17) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.08 Pain Relevance 0
After exposure to the different NPs at concentrations ranging from 0.5 to 10 ?
Gene_expression (exposure) of NPs
18) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
Smaller NPs cross the BBB more easily than do larger NPs.
Gene_expression (cross) of NPs
19) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
Similar to results with CB, exposure of neuronal networks to Fe2O3 NPs did not induce a statistically significant increase of ROS formation up to a tested concentration of 10 ?
Gene_expression (exposure) of NPs in neuronal
20) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0

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