INT159128

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 5.18
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nps) molecular_function (Nps)
Anatomy Link Frequency
heart 2
neuronal 1
nerve 1
hippocampus region 1
brain 1
Nps (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 133 99.60 Very High Very High Very High
Intracerebroventricular 3 98.64 Very High Very High Very High
Hippocampus 14 97.96 Very High Very High Very High
projection neuron 30 97.48 Very High Very High Very High
amygdala 101 96.72 Very High Very High Very High
Action potential 15 89.08 High High
depression 6 84.88 Quite High
gABA 20 84.56 Quite High
analgesia 6 78.72 Quite High
Analgesic 6 74.68 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 22 100.00 Very High Very High Very High
Neurological Disease 25 99.92 Very High Very High Very High
Diabetes Mellitus 166 99.72 Very High Very High Very High
Glioma 12 99.68 Very High Very High Very High
Sprains And Strains 4 98.80 Very High Very High Very High
Cancer 109 98.68 Very High Very High Very High
Stress 109 97.80 Very High Very High Very High
Aging 10 96.40 Very High Very High Very High
Disease 50 95.80 Very High Very High Very High
Affective Disorder 3 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, deposition and translocation of NPs in the neuronal network were observed using scanning electron microscopy and transmission electron microscopy (TEM), and acute functional toxicity, cytotoxicity, and radical formation were evaluated.
Localization (translocation) of NPs in neuronal associated with toxicity
1) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.09 Pain Relevance 0.07
Axoplasmic transport provides the mechanism to bidirectionally translocate not only organelles and viruses but also injected NPs, which are widely used neuroanatomists to trace nerve fiber connectivity (Weiss and Gorio 1982).
Localization (translocate) of NPs in nerve
2) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0.20
Intranasally instilled anatase titanium dioxide (TiO2) NPs in female mice translocated into the CNS and caused a potential lesion in the hippocampus region of the brain (Wang et al. 2008).
Localization (translocated) of NPs in hippocampus region associated with hippocampus and central nervous system
3) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.11 Pain Relevance 0.19
BACKGROUND: The heart secretes natriuretic peptides (NPs) in response to myocardial stretch.
Localization (secretes) of NPs in heart associated with natriuresis
4) Confidence 0.64 Published 2009 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 19419350 Disease Relevance 0.17 Pain Relevance 0
In all cells tested, amplitudes of eIPSCs were unaffected by application of 200 nM NPS (Figure 1I).
Localization (application) of NPS
5) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0 Pain Relevance 0.40
The natriuretic peptides (NPs), including B-type natriuretic peptide (BNP) and the N-terminal fragment of pro-BNP (NT-proBNP), are released in the setting of myocardial strain and are well established for aiding in the diagnosis, prognosis, and monitoring of heart failure patients [7].
Localization (released) of NPs in heart associated with natriuresis, sprains and strains and myocardial infarction
6) Confidence 0.61 Published 2010 Journal Curr Cardiovasc Risk Rep Section Body Doc Link PMC2894089 Disease Relevance 1.04 Pain Relevance 0
Here we confirmed the effectiveness of this carrier for brain targeting, comparing the effect obtained by the administration of loperamide-loaded NPs with the effect of an intracerebroventricular administration of the drug; moreover, the biodistribution of these NPs showed a localization into the CNS in a quantity about two orders of magnitude greater than that found with the other known NP drug carriers.
Localization (localization) of NPs in CNS associated with central nervous system and intracerebroventricular
7) Confidence 0.61 Published 2009 Journal Nanomedicine Section Abstract Doc Link 19341816 Disease Relevance 0.07 Pain Relevance 0.22
With different osmolalities but equal volumes of hydroxyethyl starch (HES)--and hypertonic saline (HS)--infusions, this double-blinded study tested the hypothesis that osmolality modulates the excretion of NPs.
Localization (excretion) of NPs
8) Confidence 0.56 Published 2009 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 19419350 Disease Relevance 0.15 Pain Relevance 0
Group III - Diabetic induced mice treated with AuNPs -DT
Localization (treated) of AuNPs associated with diabetes mellitus
9) Confidence 0.54 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.63 Pain Relevance 0
Group IV - Normal mice treated with AuNPs - NT

Induction of diabetes mellitus and treatment with AuNPs

Localization (treated) of AuNPs associated with diabetes mellitus
10) Confidence 0.54 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.64 Pain Relevance 0
Functionalization of NPs is indeed the first and perhaps foremost step towards nano-scale drug delivery systems.
Localization (Functionalization) of NPs
11) Confidence 0.35 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.64 Pain Relevance 0.28
They concluded that by transforming water-soluble hydrophilic drugs into LDC, NPs got prolonged drug release and targeting to specific sites by intravenous injection.
Localization (release) of NPs
12) Confidence 0.33 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.25 Pain Relevance 0
These NPs co-localized with glycoproteins in brain and tumour microvasculature.
Localization (localized) of NPs in brain associated with cancer
13) Confidence 0.32 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.73 Pain Relevance 0.37
Gonadotrophs may contribute to this goal by releasing NPs that in turn attenuate CRH-activated ACTH release.
Localization (releasing) of NPs in Gonadotrophs
14) Confidence 0.12 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.65 Pain Relevance 0

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