INT159139

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.73
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tail 1
lung 1
MALAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 2 99.92 Very High Very High Very High
HCN1 92 89.36 High High
headache 1 56.12 Quite High
antagonist 3 52.64 Quite High
hCN2 16 5.00 Very Low Very Low Very Low
local anesthetic 2 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 3 100.00 Very High Very High Very High
Metastasis 2 100.00 Very High Very High Very High
Lung Cancer 1 99.36 Very High Very High Very High
Cancer 7 97.88 Very High Very High Very High
Poisoning 3 95.52 Very High Very High Very High
Encephalopathy 4 93.36 High High
Stress 30 88.56 High High
Hypoxia 17 88.28 High High
Breast Cancer 11 83.28 Quite High
Death 1 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MALAT-1 (metastasis in lung adenocarcinoma transcript 1), a recently identified noncoding RNA, has been shown to be activated in early-stage lung cancer.
Positive_regulation (activated) of MALAT-1 in lung associated with adenocarcinoma, lung cancer and metastasis
1) Confidence 0.41 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.73 Pain Relevance 0.03
Many typhoons came across Japan and landed 10 times in 2004, and mushroom size was larger than usual one, and HCN contents in fruit-bodies seemed to be increased especially in the late-stage of their growth.
Positive_regulation (increased) of HCN
2) Confidence 0.37 Published 2009 Journal Chudoku Kenkyu Section Abstract Doc Link 19344063 Disease Relevance 1.01 Pain Relevance 0.06
The voltage dependence of HCN channel activation was assessed by plotting tail currents measured immediately after pulsing to ?
Positive_regulation (activation) of HCN in tail associated with addiction
3) Confidence 0.08 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.05
These P-loop and the S6 residues exert their effects by modulating drug access to the receptor and by stabilizing the drug-bound HCN channel complex.
Positive_regulation (stabilizing) of HCN
4) Confidence 0.08 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.19

General Comments

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