INT159142

Context Info Confidence 0.25 First Reported 2009 Last Reported 2010 Negated 2 Speculated 1 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.36 Pain Relevance 0.16

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Anatomy Link Frequency keratinocytes 2 Ocln (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory response 10 87.28 anesthesia 2 85.76 Inflammation 52 68.36 cytokine 16 5.00 member 8 4 5.00 Central nervous system 3 5.00 Inflammatory mediators 3 5.00 fibrosis 2 5.00 Inflammatory stimuli 2 5.00 psoriasis 2 5.00

Disease Link Frequency Relevance Heat Brain Injury 11 98.64 Aging 8 98.16 Sepsis 1 93.68 INFLAMMATION 59 87.28 Psoriasis 14 83.04 Brain Disease 1 79.68 Injury 8 76.72 Alopecia 6 68.92 Metastasis 25 50.00 Targeted Disruption 28 38.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We hypothesized that expression of tight junction protein ZO-1 and occludin, responsible for intestinal architectural and functional integrity, will decrease following TBI and increase intestinal permeability.

Regulation (responsible) of Gene_expression (expression) of occludin associated with brain injury

1) Confidence 0.25 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19344293 Disease Relevance 0.95 Pain Relevance 0.09

To determine if the down-regulation of claudin/occludin expression is a cell-autonomous effect, we analyzed the expression of these tight junction components in immortalized keratinocytes.

Spec (determine) Regulation (regulation) of Gene_expression (expression) of occludin in keratinocytes

2) Confidence 0.12 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.24 Pain Relevance 0.03

Concomitantly, expression of IL-1F8 was reduced by 30%, whereas no obvious change in the expression of claudin 1, claudin 3, or occludin was observed (unpublished data).

Neg (no) Regulation (change) of Gene_expression (expression) of occludin

3) Confidence 0.10 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.17 Pain Relevance 0.04

No alterations in the expression of occludin were detected after any PCB treatment.

Neg (No) Regulation (alterations) of Gene_expression (expression) of occludin

4) Confidence 0.09 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0

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