INT159145

Context Info Confidence 0.32 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 6 Disease Relevance 3.07 Pain Relevance 0.34

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Anatomy Link Frequency keratinocytes 4 Ocln (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 3 91.28 Inflammation 78 82.92 cytokine 24 47.16 Inflammatory response 15 5.00 member 8 6 5.00 fibrosis 3 5.00 Inflammatory stimuli 3 5.00 Inflammatory mediators 3 5.00 psoriasis 3 5.00

Disease Link Frequency Relevance Heat Brain Injury 33 99.56 Injury 15 96.04 Dermatitis 18 94.56 Sepsis 3 93.68 Brain Disease 3 85.20 Aging 12 61.40 INFLAMMATION 87 61.16 Targeted Disruption 42 54.24 Alopecia 9 32.16 Psoriasis 21 18.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We hypothesized that expression of tight junction protein ZO-1 and occludin, responsible for intestinal architectural and functional integrity, will decrease following TBI and increase intestinal permeability.

Negative_regulation (decrease) of Gene_expression (expression) of occludin associated with brain injury

1) Confidence 0.32 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19344293 Disease Relevance 1.03 Pain Relevance 0.09

Expression of ZO-1 was decreased by 49% relative to sham animals (p < 0.02), whereas expression of occludin was decreased by 73% relative to sham animals (p < 0.001).

Negative_regulation (decreased) of Gene_expression (expression) of occludin

2) Confidence 0.32 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19344293 Disease Relevance 0.87 Pain Relevance 0.07

An increase in intestinal permeability corresponds with decreased expression of tight junction proteins ZO-1 and occludin following TBI.

Negative_regulation (decreased) of Gene_expression (expression) of occludin associated with brain injury

3) Confidence 0.28 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19344293 Disease Relevance 0.73 Pain Relevance 0.07

In addition, we found that expression levels of claudins and occludin strongly declined in control mice after P18 (Fig.

Negative_regulation (declined) of Gene_expression (expression) of occludin

4) Confidence 0.22 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.05 Pain Relevance 0

EGF also induced their expression under these conditions (unpublished data), but it can obviously not compensate for the loss of FGF receptors because expression of claudin 1, claudin 3, and occludin was reduced in keratinocytes of K5-R1/R2 mice, which were cultured in the presence of EGF (Fig. 9 B).

Negative_regulation (reduced) of Gene_expression (expression) of occludin in keratinocytes

5) Confidence 0.18 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.06 Pain Relevance 0

In contrast, expression of several claudins and of occludin was much lower in the epidermis and in cultured keratinocytes of K5-R1/R2 mice.

Negative_regulation (lower) of Gene_expression (expression) of occludin in keratinocytes

6) Confidence 0.18 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.32 Pain Relevance 0.11

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