INT15916

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Context Info
Confidence 0.39
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 6.60
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgis) extracellular space (Ptgis) endoplasmic reticulum (Ptgis)
Anatomy Link Frequency
plasma 1
endothelium 1
Ptgis (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 4 98.80 Very High Very High Very High
metalloproteinase 15 96.76 Very High Very High Very High
cINOD 15 96.64 Very High Very High Very High
COX2 2 95.40 Very High Very High Very High
tetrodotoxin 2 95.00 High High
Pain 3 94.92 High High
Angina 11 90.96 High High
ischemia 3 89.64 High High
Inflammation 35 87.28 High High
antagonist 5 81.76 Quite High
Disease Link Frequency Relevance Heat
Sepsis 51 99.84 Very High Very High Very High
Myocardial Infarction 8 99.28 Very High Very High Very High
Apoptosis 24 99.12 Very High Very High Very High
Osteoid Osteoma 4 98.76 Very High Very High Very High
Disorder Of Lipid Metabolism 274 97.92 Very High Very High Very High
Coronary Heart Disease 2 97.40 Very High Very High Very High
Cancer 58 96.32 Very High Very High Very High
Pressure And Volume Under Development 7 96.20 Very High Very High Very High
INFLAMMATION 60 95.92 Very High Very High Very High
Pain 3 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostacyclin, at a dosage of 10 micrograms/min, showed maximum pulmonary vasodilation, which could not be further increased by doubling the dosage.
Neg (not) Positive_regulation (increased) of Prostacyclin
1) Confidence 0.39 Published 1996 Journal Crit. Care Med. Section Body Doc Link 8917035 Disease Relevance 0 Pain Relevance 0
Increased prostacyclin biosynthesis in patients with osteoid osteoma.
Positive_regulation (Increased) of prostacyclin associated with osteoid osteoma
2) Confidence 0.35 Published 1991 Journal Eicosanoids Section Title Doc Link 1772689 Disease Relevance 0.62 Pain Relevance 0.19
to whether prostacyclin can activate PPAR?
Positive_regulation (activate) of prostacyclin
3) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.56 Pain Relevance 0
A

connection has also been made between prostacyclin and activation of PPAR?.

Positive_regulation (activation) of prostacyclin
4) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.67 Pain Relevance 0.08
Prostacyclin biosynthesis was markedly elevated in patients with acute myocardial infarction and correlated with plasma creatine kinase (r = 0.795; P less than 0.001).
Positive_regulation (elevated) of Prostacyclin in plasma associated with myocardial infarction
5) Confidence 0.06 Published 1986 Journal N. Engl. J. Med. Section Abstract Doc Link 3531859 Disease Relevance 1.03 Pain Relevance 0.57
As PB undergoes peroxide-dependent co-oxygenation catalyzed by PHS, we propose that it is an oxygenated derivative of PB, rather than the parent compound, which is responsible for the inactivation of PHS and prostacyclin synthase.
Positive_regulation (inactivation) of prostacyclin synthase
6) Confidence 0.04 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 3917545 Disease Relevance 0 Pain Relevance 0
Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone.
Positive_regulation (Inactivation) of prostacyclin synthase
7) Confidence 0.04 Published 1985 Journal Mol. Pharmacol. Section Title Doc Link 3917545 Disease Relevance 0.10 Pain Relevance 0.10
HDL promote endothelium proliferation and diminish endothelial apoptosis; they play a key role in vasorelaxation by increasing the release of nitric oxide and prostacyclin through the induction of the expression and the activity of endothelial nitric oxide synthase and the coupling of cyclooxygenase 2 and prostacyclin synthase.
Positive_regulation (increasing) of prostacyclin in endothelium associated with cox2, apoptosis and disorder of lipid metabolism
8) Confidence 0.02 Published 2005 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC1993938 Disease Relevance 0.74 Pain Relevance 0.05
Several mechanisms underlying the effects of HDL on endothelial reactivity have been suggested, including synthesis of vasorelaxing prostanoids such as prostacyclin (PGI2) as well as activation of eNOS via SR-BI (Yuhanna et al 2001).
Positive_regulation (activation) of prostacyclin associated with disorder of lipid metabolism
9) Confidence 0.02 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.36 Pain Relevance 0
Prostacyclin was elevated in infected tissue, and its analog, carbacyclin, mimicked the altered transport response in indomethacin-treated tissue.
Positive_regulation (elevated) of Prostacyclin
10) Confidence 0.02 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8968331 Disease Relevance 0.25 Pain Relevance 0.38
In particular, thromboxane A2 and prostacyclin have been found to be elevated in sepsis [3,4].
Positive_regulation (elevated) of prostacyclin associated with sepsis
11) Confidence 0.01 Published 2004 Journal Crit Care Section Body Doc Link PMC1065065 Disease Relevance 0.66 Pain Relevance 0.10
Pharmacological and gene therapies aimed at enhancing the activity of prostacyclin, nitric oxide synthases, and Kv channels or at inhibiting endothelin and matrix metalloproteinases are promising areas for future development.
Positive_regulation (enhancing) of prostacyclin associated with metalloproteinase and potassium channel
12) Confidence 0.01 Published 2000 Journal Circulation Section Abstract Doc Link 11094047 Disease Relevance 0.62 Pain Relevance 0.28

General Comments

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