INT15917

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Context Info
Confidence 0.35
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.69
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgis) extracellular space (Ptgis) endoplasmic reticulum (Ptgis)
Anatomy Link Frequency
plasma 2
endothelial cells 2
Ptgis (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 95.44 Very High Very High Very High
cINOD 2 94.40 High High
Restless leg syndrome 1 93.24 High High
Angina 8 90.96 High High
ischemia 3 89.64 High High
fibrosis 1 78.20 Quite High
Inflammation 2 61.08 Quite High
cva 1 60.20 Quite High
Paracetamol 2 50.00 Quite Low
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Osteoid Osteoma 4 99.28 Very High Very High Very High
Myocardial Infarction 2 99.28 Very High Very High Very High
Lung Cancer 39 98.44 Very High Very High Very High
Adhesions 1 97.96 Very High Very High Very High
Coronary Heart Disease 2 97.40 Very High Very High Very High
Cancer 28 96.84 Very High Very High Very High
Disease 2 96.00 Very High Very High Very High
Pain 1 95.44 Very High Very High Very High
INFLAMMATION 3 93.68 High High
Increased Venous Pressure Under Development 1 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased prostacyclin biosynthesis in patients with osteoid osteoma.
Positive_regulation (Increased) of Gene_expression (biosynthesis) of prostacyclin associated with osteoid osteoma
1) Confidence 0.35 Published 1991 Journal Eicosanoids Section Title Doc Link 1772689 Disease Relevance 0.62 Pain Relevance 0.19
overexpressing PGIS were crossed with mice deficient in IP (A.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PGIS
2) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.57 Pain Relevance 0.03
Prostacyclin biosynthesis was markedly elevated in patients with acute myocardial infarction and correlated with plasma creatine kinase (r = 0.795; P less than 0.001).
Positive_regulation (elevated) of Gene_expression (biosynthesis) of Prostacyclin in plasma associated with myocardial infarction
3) Confidence 0.09 Published 1986 Journal N. Engl. J. Med. Section Abstract Doc Link 3531859 Disease Relevance 1.03 Pain Relevance 0.57
CONCLUSION: Acetaminophen in typical oral doses results in reduced production of prostacyclin by endothelial cells in culture and in a reduction in prostacyclin, but not thromboxane, production in pregnant women.


Positive_regulation (results) of Gene_expression (production) of prostacyclin in endothelial cells
4) Confidence 0.06 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 8475962 Disease Relevance 0 Pain Relevance 0
Prostacyclin production is generally enhanced.
Positive_regulation (enhanced) of Gene_expression (production) of Prostacyclin
5) Confidence 0.03 Published 1985 Journal Acta Vitaminol. Enzymol. Section Abstract Doc Link 3916044 Disease Relevance 1.47 Pain Relevance 0.16

General Comments

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