INT159175

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 17
Disease Relevance 15.66
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBD) transport (HBD)
Anatomy Link Frequency
reticulocytes 3
erythrocytes 2
band 2
teeth 2
monocytes 1
HBD (Homo sapiens)
Pain Link Frequency Relevance Heat
pulpitis 10 97.96 Very High Very High Very High
rheumatoid arthritis 55 90.92 High High
cytokine 17 66.84 Quite High
Inflammation 39 52.44 Quite High
ischemia 10 5.00 Very Low Very Low Very Low
psoriasis 10 5.00 Very Low Very Low Very Low
fluoxetine 7 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Gabapentin 7 5.00 Very Low Very Low Very Low
tricyclic antidepressant 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 440 99.40 Very High Very High Very High
Pulpitis 10 97.96 Very High Very High Very High
Obesity 693 97.56 Very High Very High Very High
Rheumatoid Vasculitis 5 92.08 High High
Apoptosis 147 91.72 High High
Rheumatoid Arthritis 55 90.92 High High
Malignant Neoplastic Disease 12 90.80 High High
Churg-strauss Syndrome 15 90.32 High High
Increased Venous Pressure Under Development 30 88.76 High High
Microscopic Polyangiitis 30 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We scaled the gene expression data independently by the expression of 2 erythrocyte-specific transcripts, hemoglobin D (HBD) and erythrocyte membrane protein, band 2 (EMPB2) and subjected the scaled data to gene-set enrichment analysis.
Gene_expression (expression) of hemoglobin D in band
1) Confidence 0.54 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 0.50 Pain Relevance 0
We scaled the gene expression data independently by the expression of 2 erythrocyte-specific transcripts, hemoglobin D (HBD) and erythrocyte membrane protein, band 2 (EMPB2) and subjected the scaled data to gene-set enrichment analysis.
Gene_expression (expression) of HBD in band
2) Confidence 0.54 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 0.50 Pain Relevance 0
Since the same amount of cRNA was used from each sample for hybridization, the relative enrichment of cell types is expected to have a real effect on gene expression only for genes that are differentially expressed among the cell types (e.g. hemoglobin transcripts that are expressed only in reticulocytes and not lymphocytes).
Neg (not) Gene_expression (expressed) of hemoglobin in reticulocytes
3) Confidence 0.54 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 0.42 Pain Relevance 0
Since a majority of genes upregulated in the obese subjects are highly expressed in erythrocytes and reticulocytes, we scaled the gene expression data independently by the expression of two erythrocyte-specific transcripts, hemoglobin D (HBD) and erythrocyte membrane protein, band 2 (EMPB2) and subjected the scaled data to gene-set enrichment analysis.
Gene_expression (expression) of HBD in reticulocytes associated with obesity
4) Confidence 0.54 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 1.10 Pain Relevance 0
Since a majority of genes upregulated in the obese subjects are highly expressed in erythrocytes and reticulocytes, we scaled the gene expression data independently by the expression of two erythrocyte-specific transcripts, hemoglobin D (HBD) and erythrocyte membrane protein, band 2 (EMPB2) and subjected the scaled data to gene-set enrichment analysis.
Gene_expression (expression) of hemoglobin D in reticulocytes associated with obesity
5) Confidence 0.54 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 1.10 Pain Relevance 0
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (delta) of HBD associated with vasculitis
6) Confidence 0.27 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.10 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (symptoms) of HBD associated with vasculitis
7) Confidence 0.27 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.17 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (delta) of hemoglobin associated with vasculitis
8) Confidence 0.27 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.11 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (early) of HBD associated with vasculitis
9) Confidence 0.27 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.16 Pain Relevance 0.10
In contrast, the expression of hBD-1 and hBD -4 was significantly increased in inflamed compared with healthy pulps.
Gene_expression (expression) of hBD
10) Confidence 0.27 Published 2009 Journal J Endod Section Abstract Doc Link 19345797 Disease Relevance 0.18 Pain Relevance 0.18
HBD-2 and hBD -3 were only weakly expressed in healthy and inflamed pulps.
Gene_expression (expressed) of hBD
11) Confidence 0.27 Published 2009 Journal J Endod Section Abstract Doc Link 19345797 Disease Relevance 0.18 Pain Relevance 0.18
In contrast, the expression of hBD-1 and hBD -4 was significantly increased in inflamed compared with healthy pulps.
Gene_expression (expression) of hBD
12) Confidence 0.27 Published 2009 Journal J Endod Section Abstract Doc Link 19345797 Disease Relevance 0.18 Pain Relevance 0.18
The aim of this study was to compare the gene expression of hBD-1, -2, -3, and -4 in healthy teeth and teeth with pulpitis.
Gene_expression (expression) of hBD in teeth associated with pulpitis
13) Confidence 0.27 Published 2009 Journal J Endod Section Abstract Doc Link 19345797 Disease Relevance 0.18 Pain Relevance 0.18
We previously reported that G0S2 was primarily expressed in monocytes, whereas Amphiregulin was expressed in both monocytes, T cells and B cells by performing RT–PCR on multiple-tissue cDNA panels (MTC) from Clontech (Palo Alto, CA).5 To determine whether EGR1, HBD, TVAS10, IL1R2, and calgranulin C are also expressed in particular human blood cells, we conducted similar experiments.
Gene_expression (expressed) of HBD in monocytes
14) Confidence 0.24 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.39 Pain Relevance 0.06
Since a majority of genes upregulated in the obese subjects are highly expressed in erythrocytes and reticulocytes, we scaled the gene expression data independently by the expression of two erythrocyte-specific transcripts, hemoglobin D (HBD) and erythrocyte membrane protein, band 2 (EMPB2) and subjected the scaled data to gene-set enrichment analysis.
Gene_expression (expression) of HBD in erythrocytes associated with obesity
15) Confidence 0.18 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 1.10 Pain Relevance 0
Since a majority of genes upregulated in the obese subjects are highly expressed in erythrocytes and reticulocytes, we scaled the gene expression data independently by the expression of two erythrocyte-specific transcripts, hemoglobin D (HBD) and erythrocyte membrane protein, band 2 (EMPB2) and subjected the scaled data to gene-set enrichment analysis.
Gene_expression (expression) of hemoglobin D in erythrocytes associated with obesity
16) Confidence 0.18 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 1.10 Pain Relevance 0
The aim of this study was to compare the gene expression of hBD-1, -2, -3, and -4 in healthy teeth and teeth with pulpitis.
Gene_expression (expression) of hBD in teeth associated with pulpitis
17) Confidence 0.09 Published 2009 Journal J Endod Section Abstract Doc Link 19345797 Disease Relevance 0.18 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox