INT159185

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.40
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (PSMD2) cytosol (PSMD2) nucleoplasm (PSMD2)
small molecule metabolic process (PSMD2) cellular nitrogen compound metabolic process (PSMD2)
Anatomy Link Frequency
PPC 2
organ system 2
PSMD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 7 99.84 Very High Very High Very High
Pin-prick hyperalgesia 3 99.56 Very High Very High Very High
Pain 3 98.24 Very High Very High Very High
magnetoencephalography 3 90.56 High High
Nav1.2 1 87.96 High High
Hyperalgesia 10 84.48 Quite High
c fibre 1 77.52 Quite High
Action potential 12 72.04 Quite High
sodium channel 10 68.32 Quite High
Glutamate 2 56.40 Quite High
Disease Link Frequency Relevance Heat
Nervous System Malformation 1 100.00 Very High Very High Very High
Hyperalgesia 14 99.56 Very High Very High Very High
Pain 3 98.24 Very High Very High Very High
Repression 1 62.00 Quite High
Injury 1 51.56 Quite High
Nervous System Injury 1 48.00 Quite Low
INFLAMMATION 1 47.36 Quite Low
Teratoma 10 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During pin-prick hyperalgesia significantly higher activation was detected in contralateral PPC and bilateral S2 but not in S1 compared to normal pin-prick pain.
Positive_regulation (activation) of Neg (not) Gene_expression (detected) of S2 in PPC associated with pain, hyperalgesia and pin-prick hyperalgesia
1) Confidence 0.40 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19346142 Disease Relevance 1.24 Pain Relevance 1.39
-helical as proposed for S2 segments in potassium channels?
Positive_regulation (proposed) of Gene_expression (segments) of S2 associated with potassium channel
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766034 Disease Relevance 0 Pain Relevance 0.24
Analysis of the biological processes in the beating EBs confirms these observations, with overexpression of embryonic and organ system developmental categories including nervous system development, kidney development, skeletal muscle development, and heart development (Table S2 (A8)).


Positive_regulation (overexpression) of Gene_expression (overexpression) of S2 in organ system associated with nervous system malformation
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.16 Pain Relevance 0

General Comments

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