INT15919

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.50
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
coronary artery 2
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 6 98.84 Very High Very High Very High
Angina 14 98.64 Very High Very High Very High
metalloproteinase 1 79.16 Quite High
Pain 1 68.96 Quite High
agonist 9 5.68 Low Low
cINOD 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 99.84 Very High Very High Very High
INFLAMMATION 9 98.84 Very High Very High Very High
Cv General 3 Under Development 9 98.64 Very High Very High Very High
Coronary Artery Disease 22 97.36 Very High Very High Very High
Metabolic Syndrome 4 97.16 Very High Very High Very High
Myocardial Infarction 26 97.08 Very High Very High Very High
Obesity 10 95.96 Very High Very High Very High
Syndrome 2 94.88 High High
Hyperlipidemia 3 88.16 High High
Hypertension 3 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been shown to exist in 40 to 60% of patients with stable coronary artery disease and have been suggested to be responsible for the development of coronary thrombotic complications.
Positive_regulation (Increased) of Gene_expression (levels) of PAI in coronary artery associated with coronary artery disease
1) Confidence 0.41 Published 1990 Journal Thromb. Haemost. Section Abstract Doc Link 2119522 Disease Relevance 0.78 Pain Relevance 0.39
Increased plasminogen activator inhibitor antigen levels in diabetic patients with stable angina.
Positive_regulation (Increased) of Gene_expression (levels) of plasminogen activator inhibitor associated with angina and diabetes mellitus
2) Confidence 0.20 Published 1991 Journal Blood Coagul. Fibrinolysis Section Title Doc Link 1772997 Disease Relevance 2.19 Pain Relevance 0.40
The magnitude of the risk was substantial (1.5-fold increase in risk for those with the combined ACE DD genotype and at least one PAI-1 4G allele) and comparable to that of other risk factors for which interventions are undertaken.
Positive_regulation (increase) of Gene_expression (allele) of PAI-1 4G
3) Confidence 0.18 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.10 Pain Relevance 0
Although E2 alone did not affect PAI-1 output, MPA and E2+MPA significantly enhanced PAI-1 production (2.5 +/- 0.7 vs 8.2 +/- 2.0 ng/mL per microg protein for E2+MPA [3.3-fold]; P < .01).
Positive_regulation (enhanced) of Gene_expression (production) of PAI-1
4) Confidence 0.14 Published 2007 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 17403427 Disease Relevance 0 Pain Relevance 0
negatively affects plasminogen activator by inhibiting its expression [97] and increasing the expression of plasminogen activator inhibitor-1 [97,98].
Positive_regulation (increasing) of Gene_expression (expression) of plasminogen activator inhibitor-1
5) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.04
Therefore, we propose that increased PAI-1 levels, which are essentially related to the classic metabolic aspect of the insulin resistance syndrome, have to be included in this syndrome.
Positive_regulation (increased) of Gene_expression (levels) of PAI-1 associated with syndrome and metabolic syndrome
6) Confidence 0.03 Published 1993 Journal Arterioscler. Thromb. Section Abstract Doc Link 8241109 Disease Relevance 1.43 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox