INT15921

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Context Info
Confidence 0.68
First Reported 1986
Last Reported 2011
Negated 2
Speculated 5
Reported most in Abstract
Documents 85
Total Number 90
Disease Relevance 81.24
Pain Relevance 13.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
plasma 18
coronary artery 6
endothelium 4
body 3
fat 2
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 178 99.84 Very High Very High Very High
Pain 177 99.52 Very High Very High Very High
Angina 104 99.18 Very High Very High Very High
Inflammation 135 98.84 Very High Very High Very High
Restless leg syndrome 6 98.64 Very High Very High Very High
ischemia 52 98.32 Very High Very High Very High
palliative 13 97.88 Very High Very High Very High
metalloproteinase 12 97.80 Very High Very High Very High
depression 197 97.68 Very High Very High Very High
alcohol 17 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Abdominal Injuries 23 100.00 Very High Very High Very High
Metastasis 6 99.96 Very High Very High Very High
Coronary Artery Disease 287 99.92 Very High Very High Very High
Rheumatoid Arthritis 202 99.84 Very High Very High Very High
Sepsis 11 99.84 Very High Very High Very High
Myocardial Infarction 415 99.82 Very High Very High Very High
Obesity 104 99.78 Very High Very High Very High
Insulin Resistance 186 99.76 Very High Very High Very High
Breast Cancer 36 99.64 Very High Very High Very High
Cancer 48 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ramipril prior to thrombolysis attenuates the early increase of PAI-1 in patients with acute myocardial infarction.
Positive_regulation (increase) of PAI-1 associated with myocardial infarction
1) Confidence 0.68 Published 2002 Journal Thromb. Haemost. Section Title Doc Link 12195686 Disease Relevance 0.40 Pain Relevance 0.11
We have hypothesized that increased PAI-1 can create conditions favorable to the evolution of unstable, lipid-laden atherosclerotic coronary plaques, thereby rendering patients with diabetes highly susceptible to rupture of vulnerable plaques and acute coronary syndromes.
Positive_regulation (increased) of PAI-1 in plaques associated with acute coronary syndrome, rupture, diabetes mellitus and atherosclerosis
2) Confidence 0.67 Published 2002 Journal Am. J. Med. Section Abstract Doc Link 12431758 Disease Relevance 1.11 Pain Relevance 0.05
Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been shown to exist in 40 to 60% of patients with stable coronary artery disease and have been suggested to be responsible for the development of coronary thrombotic complications.
Positive_regulation (Increased) of PAI in coronary artery associated with coronary artery disease
3) Confidence 0.61 Published 1990 Journal Thromb. Haemost. Section Abstract Doc Link 2119522 Disease Relevance 0.78 Pain Relevance 0.39
RESULTS: Ischemia led to strong upregulation of mRNA transcripts for heat shock proteins 70, 27, 105, 86 and 40 kDa, vascular endothelial growth factor, brain-derived neurotrophic factor, plasminogen activator inhibitor-1, activating transcription factor 3, B-cell translocation gene 2, and growth arrest and DNA damage inducible 45 alpha protein compared to the NI tissue.
Positive_regulation (upregulation) of plasminogen activator inhibitor-1 in brain
4) Confidence 0.59 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12909328 Disease Relevance 0.15 Pain Relevance 0
Hyperinsulinemia found in patients with angina pectoris could play a role in the development of myocardial infarction via the induction of high plasma PAI-1 activity.
Positive_regulation (induction) of PAI in plasma associated with angina, hyperinsulinism and myocardial infarction
5) Confidence 0.56 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2470343 Disease Relevance 0.70 Pain Relevance 0.24
Prospective cohort studies of patients with previous myocardial infarction or angina pectoris have underlined the association between increased plasma PAI-1 levels and the risk of coronary events, but the predictive capacity of PAI-1 disappears after insulin resistance marker adjustments.
Positive_regulation (increased) of PAI-1 in plasma associated with angina, insulin resistance and myocardial infarction
6) Confidence 0.46 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 1.00 Pain Relevance 0.10
Recently the production of PAI-1 by adipose tissue, in particular by tissue from omentum, has been demonstrated and could be an important contributor to the elevated plasma PAI-1 levels observed in insulin resistant patients.
Positive_regulation (elevated) of PAI-1 in plasma associated with obesity
7) Confidence 0.46 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 1.05 Pain Relevance 0.07
Circulating (PAI-1) levels are elevated in patients with coronary heart disease and may play an important role in the development of atherothrombosis.
Positive_regulation (elevated) of PAI-1 in heart associated with coronary artery disease
8) Confidence 0.46 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 0.76 Pain Relevance 0
PAI-1 levels in the GA group increased from 13.6 +/- 2.1 activity units (AU)/ml to 20.2 +/- 2.6 AU/ml at 24 h and returned to baseline at 72 h.
Positive_regulation (increased) of PAI-1
9) Confidence 0.46 Published 1993 Journal Anesthesiology Section Body Doc Link 8363067 Disease Relevance 0 Pain Relevance 0
Concentrations of PAI-1 are elevated in the blood and vessel walls of patients with type 2 diabetes or other insulin-resistant states.
Positive_regulation (elevated) of PAI-1 in blood associated with diabetes mellitus
10) Confidence 0.45 Published 2002 Journal Am. J. Med. Section Abstract Doc Link 12431758 Disease Relevance 0.96 Pain Relevance 0
This hormone-associated reduction of PAI-1 was observed despite increased triglycerides, a known inducer of PAI-1 levels.
Positive_regulation (inducer) of PAI-1
11) Confidence 0.39 Published 1996 Journal Am. J. Cardiol. Section Abstract Doc Link 8888658 Disease Relevance 0 Pain Relevance 0
However, it is also discussed whether PAI-1 elevation might mainly be due to variables like increased age or to reactive mechanisms caused e.g. by the chest pain itself.
Positive_regulation (elevation) of PAI in chest associated with angina
12) Confidence 0.39 Published 1990 Journal Thromb. Haemost. Section Abstract Doc Link 2119522 Disease Relevance 1.13 Pain Relevance 0.49
Differences from normal controls were observed for t-PA, PAI-1, protein C, and protein S; however, it is not certain that the thrombosis in patients with PAD is due to these factors.
Positive_regulation (observed) of PAI-1 associated with peripheral arterial disease and thrombosis
13) Confidence 0.38 Published 1996 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 8807727 Disease Relevance 0.83 Pain Relevance 0.07
can stimulate PAI-1, inhibiting the protease degradation of the ECM.
Positive_regulation (stimulate) of PAI-1
14) Confidence 0.37 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.12
The PAD patients exhibited a prothrombotic state as evidenced by high D-dimer in all but 24% of the patients (average 797 +/- 802 vs. 163 +/- 54 ng/mL normal population; p < 0.001) and high thrombin-antithrombin III complex (TAT) levels (10.2 +/- 8.9 vs. 2.5 + 1.5 ng/mL; p < 0.001) with low to normal levels of protein C (86 +/- 25 vs. 102 +/- 18%; p < 0.01) and plasminogen activator inhibitor-1 (PAI-1) antigen (5.9 +/- 4.5 vs. 1.3 + 0.7 ng/mL; p < 0.001) were elevated in 79% of the patients.
Positive_regulation (elevated) of PAI-1 associated with peripheral arterial disease
15) Confidence 0.36 Published 1996 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 8807727 Disease Relevance 0.69 Pain Relevance 0.08
The risk for 30-day mortality and/or reinfarction significantly increased in patients with admission PAI-1 levels > 4.0 U/ml (OR=4.44, 95%CI=1.47-13.4), peak PAI-1 levels > 4.0 U/ml (OR=5.78, 95%CI=1.838-18.20) and with simultaneously increased peak PAI-1 > 3.5 U/ml and TnT > 0.1 microg/l within the first 48 h (OR=4.9, 95%CI=1.569-15.385).
Positive_regulation (increased) of PAI-1
16) Confidence 0.35 Published 2004 Journal Thromb. Res. Section Body Doc Link 15381388 Disease Relevance 0.13 Pain Relevance 0
The 4G allele of the 4G/5G PAI-1 promoter polymorphism is associated with higher levels of PAI-1.
Positive_regulation (levels) of PAI-1
17) Confidence 0.34 Published 2003 Journal J. Thromb. Haemost. Section Abstract Doc Link 12911596 Disease Relevance 0.73 Pain Relevance 0.08
In contrast, plasminogen activator inhibitor-1 (PAI-1) activity in plasma was elevated in the unstable angina group (21.67 +/- 9.52 AU/ml) as compared with either the stable angina group (12.01 +/- 7.06 AU/ml, p less than 0.02) or the controls (12.49 +/- 8.54 AU/ml, p less than 0.02).
Positive_regulation (elevated) of PAI-1 in plasma
18) Confidence 0.34 Published 1991 Journal Circulation Section Body Doc Link 1902406 Disease Relevance 0.17 Pain Relevance 0
Recently the production of PAI-1 by adipose tissue, in particular by tissue from omentum, has been demonstrated and could be an important contributor to the elevated plasma PAI-1 levels observed in insulin resistant patients.
Positive_regulation (levels) of PAI-1 in plasma associated with obesity
19) Confidence 0.31 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 1.05 Pain Relevance 0.07
The PAD patients exhibited a prothrombotic state as evidenced by high D-dimer in all but 24% of the patients (average 797 +/- 802 vs. 163 +/- 54 ng/mL normal population; p < 0.001) and high thrombin-antithrombin III complex (TAT) levels (10.2 +/- 8.9 vs. 2.5 + 1.5 ng/mL; p < 0.001) with low to normal levels of protein C (86 +/- 25 vs. 102 +/- 18%; p < 0.01) and plasminogen activator inhibitor-1 (PAI-1) antigen (5.9 +/- 4.5 vs. 1.3 + 0.7 ng/mL; p < 0.001) were elevated in 79% of the patients.
Positive_regulation (elevated) of activator inhibitor-1 associated with peripheral arterial disease
20) Confidence 0.31 Published 1996 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 8807727 Disease Relevance 0.70 Pain Relevance 0.08

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