INT159212

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP4) growth (BMP4) extracellular region (BMP4)
proteinaceous extracellular matrix (BMP4)
BMP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 98.98 Very High Very High Very High
cINOD 4 76.48 Quite High
Spinal cord 6 62.16 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Intractable pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 3 99.44 Very High Very High Very High
Heterotopic Ossification 39 98.32 Very High Very High Very High
Fibrodysplasia Ossificans Progressiva 1 84.28 Quite High
Disease 1 80.88 Quite High
INFLAMMATION 1 76.08 Quite High
Spinal Cord Injury 5 62.16 Quite High
Osteoporosis 4 56.36 Quite High
Syndrome 1 49.00 Quite Low
Hemorrhage 1 46.16 Quite Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is postulated that the BMP-4 gene itself may not be defective but a defect in the genes that code BMP-4 antagonists leads to suppression of inhibitory mechanisms and overexpression of BMP-4 [24].
Positive_regulation (overexpression) of Gene_expression (overexpression) of BMP-4 associated with antagonist
1) Confidence 0.66 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2908060 Disease Relevance 0.91 Pain Relevance 0.28
RESULTS: Superpulsed laser irradiation decreases cell growth, induces expression of TGF-beta2, BMP-4, and BMP-7, type I collagen, ALP, and osteocalcin, and increases the size and the number of calcium deposits.
Positive_regulation (induces) of Gene_expression (expression) of BMP-4
2) Confidence 0.26 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0

General Comments

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