INT159213

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.10
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP4) growth (BMP4) extracellular region (BMP4)
proteinaceous extracellular matrix (BMP4)
Anatomy Link Frequency
cartilage 1
embryonic stem cell 1
BMP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 98.98 Very High Very High Very High
cINOD 4 76.48 Quite High
Spinal cord 6 62.16 Quite High
Nerve growth factor 12 17.08 Low Low
bDMF 24 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 12 99.44 Very High Very High Very High
Colon Cancer 15 99.12 Very High Very High Very High
Heterotopic Ossification 39 98.32 Very High Very High Very High
Cancer 215 93.28 High High
Breast Cancer 46 85.60 High High
Fibrodysplasia Ossificans Progressiva 1 84.28 Quite High
Adhesions 17 83.84 Quite High
Disease 36 80.88 Quite High
Leukemia 11 79.80 Quite High
Bladder Cancer 7 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is postulated that the BMP-4 gene itself may not be defective but a defect in the genes that code BMP-4 antagonists leads to suppression of inhibitory mechanisms and overexpression of BMP-4 [24].
Gene_expression (overexpression) of BMP-4 associated with antagonist
1) Confidence 0.74 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2908060 Disease Relevance 0.91 Pain Relevance 0.28
Bone morphogenic protein 4 (BMP4) was also selectively expressed by SMCs isolated from urinary tract structures (Figure 4C).
Gene_expression (expressed) of BMP4
2) Confidence 0.62 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.08 Pain Relevance 0
The expression of the BMP4 and LIF/OSM receptor in urinary tract SMCs may be a vestige of their developmental origins and suggests the possibility that these cells may retain some of the developmental plasticity of their progenitors.
Gene_expression (expression) of BMP4
3) Confidence 0.62 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0 Pain Relevance 0
Bone morphogenic protein 4 (BMP4) was also selectively expressed by SMCs isolated from urinary tract structures (Figure 4C).
Gene_expression (expressed) of Bone morphogenic protein 4
4) Confidence 0.62 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.08 Pain Relevance 0
It is more likely that we failed to detect BMP4 expression because it is restricted to cartilage or other tissues included in the Feng and colleagues study but not in the present one.
Gene_expression (expression) of BMP4 in cartilage
5) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
Negative results were also obtained for CDH4, Galanin, BMP4 and CNTF.
Gene_expression (obtained) of BMP4
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.08 Pain Relevance 0
RESULTS: Superpulsed laser irradiation decreases cell growth, induces expression of TGF-beta2, BMP-4, and BMP-7, type I collagen, ALP, and osteocalcin, and increases the size and the number of calcium deposits.
Gene_expression (expression) of BMP-4
7) Confidence 0.41 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0
The gene encoding BMP4 is also highly expressed in the human trophectoderm [16] and has been shown to promote human embryonic stem cell differentiation into trophoblasts [17].
Gene_expression (expressed) of BMP4 in embryonic stem cell
8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0 Pain Relevance 0
Six proteins (ANXA3, BMP4, LCN2, SPARC, MMP7, and MMP11) were found to be over-expressed in colorectal tumoral tissues by using immunoblotting and tissue microarray analysis.
Gene_expression (expressed) of BMP4
9) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.95 Pain Relevance 0

General Comments

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