INT159214

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.16
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (BMP7) extracellular space (BMP7) growth (BMP7)
extracellular region (BMP7)
Anatomy Link Frequency
knees 2
dentin 2
BMP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 27 98.60 Very High Very High Very High
Osteoarthritis 17 98.44 Very High Very High Very High
pulpitis 1 94.76 High High
metalloproteinase 8 75.44 Quite High
rheumatoid arthritis 1 75.16 Quite High
Inflammation 12 49.12 Quite Low
antagonist 2 34.08 Quite Low
Facet joint 38 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Squamous Cell Carcinoma 61 99.80 Very High Very High Very High
Intervertebral Disk Degeneration 68 99.52 Very High Very High Very High
Osteoarthritis 29 98.44 Very High Very High Very High
Adenocarcinoma 62 97.94 Very High Very High Very High
Pulpitis 1 94.76 High High
Rheumatoid Arthritis 2 75.32 Quite High
Aging 7 67.64 Quite High
Hypertrophy 1 56.44 Quite High
Cytomegalovirus Infection 4 53.76 Quite High
Osteoporosis 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Positive_regulation (increase) of Gene_expression (expression) of BMP-7
1) Confidence 0.46 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
These results support that both AD and SCC subtypes have suppressed TGF-beta signaling but through different mechanisms: in SCC there is increased expression of BMP7 that antagonizes TGF-beta functions [39], and reduced expression of TGFBR2, which suggests that SCC might be more sensitive than AD to targeting BMP7 or increasing expression of TGFBR2.
Positive_regulation (increased) of Gene_expression (expression) of BMP7 associated with squamous cell carcinoma and adenocarcinoma
2) Confidence 0.43 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.09 Pain Relevance 0
This is supported by the data of Honsawek et al., who described increased BMP-7 levels in knees of patients with progressive OA [19] The circumstance that in our trial only patients with circumscribed cartilage lesions were included (and patients with advanced OA were excluded) may make clear why synovial concentrations were mainly found below the detection level and, therefore, did not correlate with the clinical score.
Positive_regulation (increased) of Gene_expression (levels) of BMP-7 in knees associated with osteoarthritis
3) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.66 Pain Relevance 0.23
Six weeks after the OP-1 injection, a restoration of disc height and MRI changes were observed and sustained for the entire experimental period, up to 24 weeks (Fig. 2).62 In another degeneration model using C-ABC, 4 weeks following the injection of C-ABC, OP-1 (100¼g/disc) injection restored the disc height up to 12 weeks after the OP-1 injection.63 These data suggest that OP-1 may be utilized in patients with disc degeneration who had received chemonucleolysis in the past that resulted in some loss of disc height.


Positive_regulation (weeks) of Gene_expression (injection) of OP-1 associated with intervertebral disk degeneration and imagery
4) Confidence 0.40 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.24 Pain Relevance 0.14
RESULTS: Superpulsed laser irradiation decreases cell growth, induces expression of TGF-beta2, BMP-4, and BMP-7, type I collagen, ALP, and osteocalcin, and increases the size and the number of calcium deposits.
Positive_regulation (induces) of Gene_expression (expression) of BMP-7
5) Confidence 0.26 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0
Transfer of BMP-7 ex vivo transduced autologous dermal fibroblasts in a collagen hydrogel into an experimentally-induced ferret model of reversible pulpitis induces reparative dentinogenesis and regeneration of the dentin-pulp complex [25].
Positive_regulation (Transfer) of Gene_expression (Transfer) of BMP-7 in dentin associated with pulpitis
6) Confidence 0.13 Published 2006 Journal Head Face Med Section Body Doc Link PMC1481630 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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