INT15922

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Context Info
Confidence 0.31
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 8.34
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
plasma 4
coronary artery 4
fat 2
endothelium 2
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 3 99.32 Very High Very High Very High
depression 98 97.68 Very High Very High Very High
substance P 21 93.36 High High
ischemia 11 92.00 High High
Pain 82 88.24 High High
Angina 9 83.40 Quite High
methotrexate 1 81.36 Quite High
antidepressant 2 58.16 Quite High
Inflammation 9 55.44 Quite High
cytokine 5 50.56 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 55 99.24 Very High Very High Very High
Diabetes Mellitus 195 98.90 Very High Very High Very High
Adhesions 2 98.88 Very High Very High Very High
Obesity 14 97.86 Very High Very High Very High
Depression 105 97.68 Very High Very High Very High
Cancer 4 95.36 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 1 91.92 High High
Insulin Resistance 26 91.08 High High
Abdominal Obesity 5 89.40 High High
Pain 84 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently the production of PAI-1 by adipose tissue, in particular by tissue from omentum, has been demonstrated and could be an important contributor to the elevated plasma PAI-1 levels observed in insulin resistant patients.
Positive_regulation (elevated) of Positive_regulation (levels) of PAI-1 in plasma associated with obesity
1) Confidence 0.31 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 1.06 Pain Relevance 0.07
Because only diabetics with coronary artery disease (CAD) showed a decreased fibrinolytic capacity, a second study was performed on the 16 non-diabetic CAD patients to determine whether submaximal workload induces significant changes of tPA and PAI levels.
Spec (whether) Positive_regulation (induces) of Spec (whether) Positive_regulation (changes) of PAI in coronary artery associated with coronary artery disease and diabetes mellitus
2) Confidence 0.20 Published 1991 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 1772997 Disease Relevance 2.41 Pain Relevance 0.38
Several studies have demonstrated an increased level of plasma plasminogen activator inhibitor-1 (PAI-1) in patients with coronary artery disease (CAD).
Positive_regulation (increased) of Positive_regulation (level) of PAI-1 in coronary artery associated with coronary artery disease
3) Confidence 0.18 Published 2000 Journal Jpn. Circ. J. Section Abstract Doc Link 10952148 Disease Relevance 0.83 Pain Relevance 0.08
Preservation of circadian pattern in PAI plasma levels despite myocardial ischemic attacks indicates that elevation of PAI is rather not caused by a reactive phenomenon.
Neg (not) Positive_regulation (caused) of Positive_regulation (elevation) of PAI in plasma
4) Confidence 0.15 Published 1988 Journal Thromb. Haemost. Section Abstract Doc Link 3149044 Disease Relevance 0.97 Pain Relevance 0.12
These findings suggest that high levels of uPA and/or PAI-1 do reflect an aggressive phenotype that may be overcome or suppressed by early systemic therapy in the adjuvant setting but may be too advanced for response to palliative therapy at a later stage.
Positive_regulation (advanced) of Positive_regulation (levels) of PAI-1 associated with palliative
5) Confidence 0.15 Published 2004 Journal Clin. Breast Cancer Section Abstract Doc Link 15585071 Disease Relevance 0.94 Pain Relevance 0.24
In the cardiac endothelium, AGEĀ–RAGE interaction leads to upregulation of procoagulant and adhesive proteins, including tissue factor, plasminogen activator inhibitor 1 (PAI-1), and vascular cell adhesion molecule 1 (VCAM-1).
Positive_regulation (leads) of Positive_regulation (upregulation) of plasminogen activator inhibitor 1 in endothelium associated with adhesions
6) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 0.81 Pain Relevance 0.05
In addition, they had increased abdominal fat and higher levels of plasminogen activator-1 and Factor VIII [13].
Positive_regulation (increased) of Positive_regulation (levels) of plasminogen activator-1 in fat
7) Confidence 0.01 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1373611 Disease Relevance 1.33 Pain Relevance 1.21

General Comments

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