INT159221

Context Info Confidence 0.41 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 4.22 Pain Relevance 0.43

cell proliferation (TBX1) nucleus (TBX1) DNA binding (TBX1)

Anatomy Link Frequency vertebral body 1 body 1 TBX1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 37 99.98 cva 3 86.56 palliative 1 74.76 analgesia 2 68.08 cytokine 9 5.00 Inflammation 7 5.00 anesthesia 6 5.00 Chronic pancreatitis 6 5.00 backache 6 5.00 imagery 4 5.00

Disease Link Frequency Relevance Heat Compression Fractures 156 100.00 Pain 32 99.98 Ventricular Heart Septal Defects 8 99.84 Disease 14 97.04 Kyphosis 7 94.00 Death 4 90.36 Paralysis 2 89.84 Adult Respiratory Distress Syndrome 2 89.48 Infection 2 87.36 Fracture Healing 10 86.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A primer pair (ConForw: ctg gac tct gac atg tgc aca tac; ConRev: cta cat gca gga tga cca gca tag) complementary for Connexin 31 was used as a control (data not shown).

Negative_regulation (gga) of tga

1) Confidence 0.41 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.20 Pain Relevance 0

This new condition is not surprising knowing that 75% of the VSDs must be enlarged preventively in DORV-nc-VSD repair.

Negative_regulation (preventively) of DORV associated with ventricular heart septal defects

2) Confidence 0.28 Published 2009 Journal Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu Section Abstract Doc Link 19349027 Disease Relevance 0.94 Pain Relevance 0.07

The postoperative use of anti- osteoporotic medication is recommended for the prevention of new VCFs.

Negative_regulation (prevention) of VCFs associated with compression fractures

3) Confidence 0.21 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628047 Disease Relevance 0.77 Pain Relevance 0

Although PMMA vertebroplasty is successful for pain relief in VCFs,17234243 this technique does not attempt to restore the height of the collapsed vertebral body.

Negative_regulation (relief) of VCFs in vertebral body associated with compression fractures and pain

4) Confidence 0.12 Published 2010 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2856395 Disease Relevance 1.07 Pain Relevance 0.18

Another minimally invasive method, i.e. transpedicle body augmentation (TpBA) with titanium spacers was reported to treat VCFs effectively.33 Manual reduction and TpBA were initially applied to restore burst fractures and Kümmell's disease with cord compression.34–37 The concept is that a fractured body can be reduced by manual reduction and reconstructed with TpBA via a posterior approach.

Negative_regulation (reduction) of VCFs in body associated with compression fractures and disease

5) Confidence 0.12 Published 2010 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2856395 Disease Relevance 1.24 Pain Relevance 0.17

General Comments

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