INT159231

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.39
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PDGFRA) nucleus (PDGFRA) extracellular matrix organization (PDGFRA)
cytoplasm (PDGFRA)
Anatomy Link Frequency
thyroid 1
platelet 1
PDGFRA (Homo sapiens)
Pain Link Frequency Relevance Heat
Dysuria 1 83.56 Quite High
methotrexate 1 67.20 Quite High
cINOD 5 58.00 Quite High
imagery 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 77 99.70 Very High Very High Very High
Metastasis 10 97.28 Very High Very High Very High
Small Cell Lung Cancer 5 96.20 Very High Very High Very High
Disease 12 92.12 High High
Gastrointestinal Stromal Tumor 21 87.40 High High
Carcinoma 1 85.40 High High
Desmoid Disease 27 84.24 Quite High
Recurrence 17 74.72 Quite High
Weight Loss 1 62.12 Quite High
Amputation 1 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry of the tumorectomy and autopsy specimens was positive for cytokeratins, neuron-specific enolase, synaptophysin, CD56, KIT and PDGFRA, and negative for chromogranin and thyroid transcriptional factor-1.
Positive_regulation (positive) of PDGFRA in thyroid
1) Confidence 0.47 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19351368 Disease Relevance 0.61 Pain Relevance 0.08
This effect is presumably due to tumor expression of activated receptor tyrosine kinases c-kit and/or platelet-derived growth factor receptor-alpha (PDGFRA).
Positive_regulation (activated) of PDGFRA in platelet associated with cancer
2) Confidence 0.45 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2438440 Disease Relevance 0.73 Pain Relevance 0.09
In all, 56 of these patients had tumors with KIT exon 11 mutations (41 deletions, 9 missense mutations, 6 duplications); two tumors had duplication mutations in KIT exon 9, and one tumor had a missense mutation in PDGFRA exon 12.
Positive_regulation (mutation) of PDGFRA associated with cancer
3) Confidence 0.21 Published 2010 Journal World J Surg Section Body Doc Link PMC2917560 Disease Relevance 1.05 Pain Relevance 0

General Comments

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