INT159276

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Anatomy Link Frequency
liver 1
kidney 1
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 35 100.00 Very High Very High Very High
cytokine 3 100.00 Very High Very High Very High
adenocard 5 99.96 Very High Very High Very High
gABA 8 99.78 Very High Very High Very High
spinal dorsal horn 38 97.92 Very High Very High Very High
Morphine 4 93.96 High High
Paracetamol 4 87.88 High High
Opioid 3 80.48 Quite High
Cholecystokinin 5 79.60 Quite High
Serotonin 5 78.48 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 100.00 Very High Very High Very High
Nociception 20 97.24 Very High Very High Very High
Acute-phase Reaction 2 75.00 Quite High
Injury 5 70.88 Quite High
Pain 10 57.56 Quite High
Hypoalagesia 3 51.52 Quite High
Nervous System Injury 1 49.80 Quite Low
Urological Neuroanatomy 3 39.84 Quite Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endotoxin administration was associated with a time-dependent decrease in UGT1A1, UGT1A6, UGT2B1, and UGT2B3 mRNA levels in liver and kidney tissues.
Transcription (levels) of UGT1A6 in kidney
1) Confidence 0.60 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31
Endotoxin administration was associated with a time-dependent decrease in UGT1A1, UGT1A6, UGT2B1, and UGT2B3 mRNA levels in liver and kidney tissues.
Transcription (levels) of UGT1A6 in liver
2) Confidence 0.20 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.31
These include genes encoding GAD65 GABA synthesis enzyme, anti-inflammatory cytokine, IL-10, and GABAB1d, A1 adenosine, ?
Transcription (enzyme) of A1 associated with adenocard, gaba, inflammation and cytokine
3) Confidence 0.08 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.66 Pain Relevance 0.72

General Comments

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